A new look at the origins of gibbon ape leukemia virus

McKee, J., Clark, N., Shapter, F. and Simmons, G. (2017) A new look at the origins of gibbon ape leukemia virus. Virus Genes, 53 2: 165-172. doi:10.1007/s11262-017-1436-0

Author McKee, J.
Clark, N.
Shapter, F.
Simmons, G.
Title A new look at the origins of gibbon ape leukemia virus
Journal name Virus Genes   Check publisher's open access policy
ISSN 1572-994X
Publication date 2017-04-01
Sub-type Article (original research)
DOI 10.1007/s11262-017-1436-0
Open Access Status Not yet assessed
Volume 53
Issue 2
Start page 165
End page 172
Total pages 8
Place of publication New York, United States
Publisher Springer
Language eng
Subject 1312 Molecular Biology
1311 Genetics
2406 Virology
Abstract Is the origin of gibbon ape leukemia virus (GALV) human after all? When GALV was discovered and found to cause neoplastic disease in gibbons, it stimulated a great deal of research including investigations into the origins of this virus. A number of publications have suggested that the GALV progenitor was a retrovirus present in one of several species of South East Asian rodents that had close contact with captive gibbons. However, there are no published retroviral sequences from any South East Asian species to support this view. Here we present an alternative hypothesis that the origin of GALV is a virus closely related to Melomys burtoni retrovirus, and that this virus infected human patients in Papua New Guinea from whom biological material was obtained or in some way contaminated these samples. This material we propose contained infectious MbRV-related virus that was then unwittingly introduced into gibbons which subsequently developed GALV infections.
Keyword Gibbon ape leukemia virus, GALV
Koala retrovirus, KoRV
Melomys burtoni retrovirus, MbRV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
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