Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations

Robiou-du-Pont, Sebastien, Yengo, Loic, Vaillant, Emmanuel, Lobbens, Stephane, Durand, Emmanuelle, Horber, Fritz, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Froguel, Philippe and Meyre, David (2013) Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. Journal of Molecular Medicine, 91 9: 1109-1115. doi:10.1007/s00109-013-1027-z


Author Robiou-du-Pont, Sebastien
Yengo, Loic
Vaillant, Emmanuel
Lobbens, Stephane
Durand, Emmanuelle
Horber, Fritz
Lantieri, Olivier
Marre, Michel
Balkau, Beverley
Froguel, Philippe
Meyre, David
Title Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
Formatted title
Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
Journal name Journal of Molecular Medicine   Check publisher's open access policy
ISSN 0946-2716
1432-1440
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00109-013-1027-z
Open Access Status Not yet assessed
Volume 91
Issue 9
Start page 1109
End page 1115
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract We investigated the effect of 24 obesity-predisposing single nucleotide polymorphisms (SNPs), separately and in combination, on snacking behavior in three European populations. The 24 SNPs were genotyped in 7,502 subjects (1,868 snackers and 5,634 non-snackers). We tested the hypothesis that obesity risk variants or a genetic risk score increases snacking using a logistic regression adjusted for sex, age, and body mass index. The obesity genetic risk score was not associated with snacking (odds ratio (OR) = 1.00 [0.98–1.02], P value = 0.48). The obesity risk variants of two SNPs (rs925946 and rs7498665) close to the BDNF and SH2B1 genes showed nominal evidence of association with increased snacking (OR = 1.09 [1.01–1.17], P value = 0.0348 and OR = 1.11 [1.04–1.19], P value = 0.00703, respectively) but did not survive Bonferroni corrections for multiple testing. The associations of rs925946 and rs7498665 obesity risk variants with increased BMI (β = 0.180 [0.022–0.339], P value = 0.0258 and β = 0.166 [0.019–0.313], P value = 0.0271, respectively) were slightly attenuated after adjusting for snacking (β = 0.151 [−0.006 to 0.309], P value = 0.0591 and β = 0.152 [0.006–0.297], P value = 0.0413). Our data suggest that genetic predisposition to obesity does not significantly contribute to snacking behavior. The nominal associations of rs925946 and rs7498665 obesity risk variants near the BDNF and SH2B1 genes with increased snacking deserve further investigation.
Keyword BDNF
Genome-wide association
Obesity
SH2B1
Single nucleotide polymorphism
Snacking behavior
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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