European genetic variants associated with type 2 diabetes in North African Arabs

Cauchi, S., Ezzidi, I., El Achhab, Y., Mtiraoui, N., Chaieb, L., Salah, D., Nejjari, C., Labrune, Y., Yengo, L., Beury, D., Vaxillaire, M., Mahjoub, T., Chikri, M. and Froguel, P. (2012) European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes and Metabolism, 38 4: 316-323. doi:10.1016/j.diabet.2012.02.003


Author Cauchi, S.
Ezzidi, I.
El Achhab, Y.
Mtiraoui, N.
Chaieb, L.
Salah, D.
Nejjari, C.
Labrune, Y.
Yengo, L.
Beury, D.
Vaxillaire, M.
Mahjoub, T.
Chikri, M.
Froguel, P.
Title European genetic variants associated with type 2 diabetes in North African Arabs
Journal name Diabetes and Metabolism   Check publisher's open access policy
ISSN 1262-3636
1878-1780
Publication date 2012-10-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.diabet.2012.02.003
Open Access Status Not yet assessed
Volume 38
Issue 4
Start page 316
End page 323
Total pages 8
Place of publication Cedex, France
Publisher Elsevier Masson
Language eng
Formatted abstract
Aims: Recent genome-wide association studies (GWAS) and previous approaches have identified many genetic variants associated with type 2 diabetes (T2D) in populations of European descent, but their contribution in Arab populations from North Africa is unknown. Our study aimed to validate these markers and to assess their combined effects, using large case-control studies of Moroccan and Tunisian individuals.

Methods: Overall, 44 polymorphisms, located at 37 validated European loci, were first analyzed in 1055 normoglycaemic controls and 1193 T2D cases from Morocco. Associations and trends were then assessed in 942 normoglycaemic controls and 1446 T2D cases from Tunisia. Finally, their ability to discriminate cases from controls was evaluated.

Results: Carrying a genetic variant in BCL11A, ADAMTS9, IGF2BP2, WFS1, CDKAL1, TP53INP1, CDKN2A/B, TCF7L2, KCNQ1, HNF1A, FTO, MC4R and GCK increased the risk of T2D when assessing the Moroccan and Tunisian samples together. Each additional risk allele increased the susceptibility for developing the disease by 12% (=9.0×10-9). Genotype information for 13 polymorphisms slightly improved the classification of North Africans with and without T2D, as assessed by clinical parameters, with an increase in the area under the receiver operating characteristic curve from 0.64 to 0.67 (P=0.004).

Conclusion: In addition to TCF7L2, 12 additional loci were found to be shared between Europeans and North African Arabs. As for Europeans, the reliability of genetic testing based on these markers to determine the risk for T2D is low. More genome-wide studies, including next-generation sequencing, in North African populations are needed to identify the genetic variants responsible for ethnic disparities in T2D susceptibility.
Keyword Morocco
Polymorphism
Tunisia
Type 2 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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