Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Bonnefond, Amelie, Skrobek, Boris, Lobbens, Stephane, Eury, Elodie, Thuillier, Dorothee, Cauchi, Stephane, Lantieri, Olivier, Balkau, Beverley, Riboli, Elio, Marre, Michel, Charpentier, Guillaume, Yengo, Loic and Froguel, Philippe (2013) Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nature Genetics, 45 9: 1040-1043. doi:10.1038/ng.2700


Author Bonnefond, Amelie
Skrobek, Boris
Lobbens, Stephane
Eury, Elodie
Thuillier, Dorothee
Cauchi, Stephane
Lantieri, Olivier
Balkau, Beverley
Riboli, Elio
Marre, Michel
Charpentier, Guillaume
Yengo, Loic
Froguel, Philippe
Title Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-07-14
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2700
Open Access Status Not yet assessed
Volume 45
Issue 9
Start page 1040
End page 1043
Total pages 4
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging and to predict cancer. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease and is associated with higher prevalence of cancers. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3; P = 5.1 × 10-5) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6; P = 4.9 × 10-5). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively; P = 7.7 × 10-4). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (P = 8.60 × 10-3). In conclusion, given the increased risk of cancer in CME carriers, our results may have profound clinical implications in patients with severe T2D.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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