Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis

Favennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016) Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 6: . doi:10.1371/journal.pone.0158051

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Author Favennec, Marie
Hennart, Benjamin
Verbanck, Marie
Pigeyre, Marie
Caiazzo, Robert
Raverdy, Violeta
Verkindt, Helene
Leloire, Audrey
Guillemin, Gilles J.
Yengo, Loic
Allorge, Delphine
Froguel, Philippe
Pattou, Francois
Poulain-Godefroy, Odile
Title Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis
Journal name Plos One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.pone.0158051
Open Access Status DOI
Volume 11
Issue 6
Total pages 12
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background
An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue. Bariatric surgery decreases low-grade inflammation associated with obesity and improves glucose control.

Objective
Our goal was to determine the concentrations of all kynurenine metabolites after bariatric surgery and whether they were correlated with glucose control improvement.

Design
Kynurenine metabolite concentrations, analysed by liquid or gas chromatography coupled with tandem mass spectrometry, circulating inflammatory markers, metabolic traits, and BMI were measured before and one year after bariatric surgery in 44 normoglycemic and 47 diabetic women with obesity. Associations between changes in kynurenine metabolites concentrations and in glucose control and metabolic traits were analysed between baseline and twelve months after surgery.

Results
Tryptophan and kynurenine metabolite concentrations were significantly decreased one year after bariatric surgery and were correlated with the decrease of the usCRP in both groups. Among all the kynurenine metabolites evaluated, only quinolinic acid and xanthurenic acid were significantly associated with glucose control improvement. The one year delta of quinolinic acid concentrations was negatively associated with the delta of fasting glucose (p = 0.019) and HbA1c (p = 0.014), whereas the delta of xanthurenic acid was positively associated with the delta of insulin sensitivity index (p = 0.0018).

Conclusion
Bariatric surgery has induced a global down-regulation of kynurenine metabolites, associated with weight loss. Our results suggest that, since kynurenine monoxygenase diverts the kynurenine pathway toward the synthesis of xanthurenic acid, its inhibition may also contribute to glucose homeostasis.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ANR-10-LABX-46
ARCF20100397
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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