Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children

Mejia-Bentez, Maria A., Bonnefond, Amelie, Yengo, Loic, Huyvaert, Marlene, Dechaume, Aurelie, Peralta-Romero, Jesus, Kluender-Kluender, Miguel, Garcia Mena, Jaime, Moustafa, Julia S. El-Sayed, Falchi, Mario, Cruz, Miguel and Froguel, Philippe (2015) Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia, 58 2: 290-294. doi:10.1007/s00125-014-3441-3


Author Mejia-Bentez, Maria A.
Bonnefond, Amelie
Yengo, Loic
Huyvaert, Marlene
Dechaume, Aurelie
Peralta-Romero, Jesus
Kluender-Kluender, Miguel
Garcia Mena, Jaime
Moustafa, Julia S. El-Sayed
Falchi, Mario
Cruz, Miguel
Froguel, Philippe
Title Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children
Formatted title
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children
Journal name Diabetologia   Check publisher's open access policy
ISSN 1432-0428
0012-186X
Publication date 2015-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s00125-014-3441-3
Open Access Status Not yet assessed
Volume 58
Issue 2
Start page 290
End page 294
Total pages 5
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Aims/hypothesis: Childhood obesity is a major public health problem in Mexico, affecting one in every three children. Genome-wide association studies identified genetic variants associated with childhood obesity, but a large missing heritability remains to be elucidated. We have recently shown a strong association between a highly polymorphic copy number variant encompassing the salivary amylase gene (AMY1 also known as AMY1A) and obesity in European and Asian adults. In the present study, we aimed to evaluate the association between AMY1 copy number and obesity in Mexican children.

Methods: We evaluated the number of AMY1 copies in 597 Mexican children (293 obese children and 304 normal weight controls) through highly sensitive digital PCR. The effect of AMY1 copy number on obesity status was assessed using a logistic regression model adjusted for age and sex.

Results: We identified a marked effect of AMY1 copy number on reduced risk of obesity (OR per estimated copy 0.84, with the number of copies ranging from one to 16 in this population; p = 4.25 × 10−6). The global association between AMY1 copy number and reduced risk of obesity seemed to be mostly driven by the contribution of the highest AMY1 copy number. Strikingly, all children with >10 AMY1 copies were normal weight controls.

Conclusions/interpretation: Salivary amylase initiates the digestion of dietary starch, which is highly consumed in Mexico. Our current study suggests putative benefits of high number of AMY1 copies (and related production of salivary amylase) on energy metabolism in Mexican children.
Keyword AMY1
AMY1A
Childhood obesity
CNV
Copy number variation
Digital PCR
Genetics
Mexican children
Salivary amylase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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