Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna, Ang, Wei, Atalay, Mustafa, Bisgaard, Hans, Blakemore, Alexandra I., Bonnefond, Amelie, Carstensen, Lisbeth, Eriksson, Johan, Flexeder, Claudia, Franke, Lude, Geller, Frank, Geserick, Mandy, Hartikainen, Anna-Liisa, Haworth, Claire M. A., Hirschhorn, Joel N., Hofman, Albert, Holm, Jens-Christian, Horikoshi, Momoko, Hottenga, Jouke Jan, Huang, Jinyan, Kadarmideen, Haja N., Kahonen, Mika, Kiess, Wieland, Lakka, Hanna-Maaria, Lakka, Timo A., Lewin, Alexandra M., Liang, Liming, Lyytikainen, Leo-Pekka, Ma, Baoshan, Magnus, Per, McCormack, Shana E., McMahon, George, Mentch, Frank D., Middeldorp, Christel M., Murray, Clare S., Pahkala, Katja, Pers, Tune H., Pfaefle, Roland, Postma, Dirkje S., Power, Christine, Simpson, Angela, Sengpiel, Verena, Tiesler, Carla M. T., Torrent, Maties, Uitterlinden, Andre G., van Meurs, Joyce B., Vinding, Rebecca, Waage, Johannes, Wardle, Jane, Zeggini, Eleftheria, Zemel, Babette S., Dedoussis, George V., Pedersen, Oluf, Froguel, Philippe, Sunyer, Jordi, Plomin, Robert, Jacobsson, Bo, Hansen, Torben, Gonzalez, Juan R., Custovic, Adnan, Raitakari, Olli T., Pennell, Craig E., Widen, Elisabeth, Boomsma, Dorret I., Koppelman, Gerard H., Sebert, Sylvain, Jarvelin, Marjo-Riitta, Hypponen, Elina, McCarthy, Mark I., Lindi, Virpi, Harri, Niinikoski, Koerner, Antje, Bonnelykke, Klaus, Heinrich, Joachim, Melbye, Mads, Rivadeneira, Fernando, Hakonarson, Hakon, Ring, Susan M., Smith, George Davey, Sorensen, Thorkild I. A., Timpson, Nicholas J., Grant, Struan F. A. and Jaddoe, Vincent W. V. (2016) Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 2: 389-403. doi:10.1093/hmg/ddv472


Author Felix, Janine F.
Bradfield, Jonathan P.
Monnereau, Claire
van der Valk, Ralf J. P.
Stergiakouli, Evie
Chesi, Alessandra
Gaillard, Romy
Feenstra, Bjarke
Thiering, Elisabeth
Kreiner-Moller, Eskil
Mahajan, Anubha
Pitkanen, Niina
Joro, Raimo
Cavadino, Alana
Huikari, Ville
Franks, Steve
Groen-Blokhuis, Maria M.
Cousminer, Diana L.
Marsh, Julie A.
Lehtimaki, Terho
Curtin, John A.
Vioque, Jesus
Ahluwalia, Tarunveer S.
Myhre, Ronny
Price, Thomas S.
Vilor-Tejedor, Natalia
Yengo, Loic
Grarup, Niels
Ntalla, Ioanna
Ang, Wei
Atalay, Mustafa
Bisgaard, Hans
Blakemore, Alexandra I.
Bonnefond, Amelie
Carstensen, Lisbeth
Eriksson, Johan
Flexeder, Claudia
Franke, Lude
Geller, Frank
Geserick, Mandy
Hartikainen, Anna-Liisa
Haworth, Claire M. A.
Hirschhorn, Joel N.
Hofman, Albert
Holm, Jens-Christian
Horikoshi, Momoko
Hottenga, Jouke Jan
Huang, Jinyan
Kadarmideen, Haja N.
Kahonen, Mika
Kiess, Wieland
Lakka, Hanna-Maaria
Lakka, Timo A.
Lewin, Alexandra M.
Liang, Liming
Lyytikainen, Leo-Pekka
Ma, Baoshan
Magnus, Per
McCormack, Shana E.
McMahon, George
Mentch, Frank D.
Middeldorp, Christel M.
Murray, Clare S.
Pahkala, Katja
Pers, Tune H.
Pfaefle, Roland
Postma, Dirkje S.
Power, Christine
Simpson, Angela
Sengpiel, Verena
Tiesler, Carla M. T.
Torrent, Maties
Uitterlinden, Andre G.
van Meurs, Joyce B.
Vinding, Rebecca
Waage, Johannes
Wardle, Jane
Zeggini, Eleftheria
Zemel, Babette S.
Dedoussis, George V.
Pedersen, Oluf
Froguel, Philippe
Sunyer, Jordi
Plomin, Robert
Jacobsson, Bo
Hansen, Torben
Gonzalez, Juan R.
Custovic, Adnan
Raitakari, Olli T.
Pennell, Craig E.
Widen, Elisabeth
Boomsma, Dorret I.
Koppelman, Gerard H.
Sebert, Sylvain
Jarvelin, Marjo-Riitta
Hypponen, Elina
McCarthy, Mark I.
Lindi, Virpi
Harri, Niinikoski
Koerner, Antje
Bonnelykke, Klaus
Heinrich, Joachim
Melbye, Mads
Rivadeneira, Fernando
Hakonarson, Hakon
Ring, Susan M.
Smith, George Davey
Sorensen, Thorkild I. A.
Timpson, Nicholas J.
Grant, Struan F. A.
Jaddoe, Vincent W. V.
Title Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 1460-2083
0964-6906
Publication date 2016-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/hmg/ddv472
Open Access Status Not yet assessed
Volume 25
Issue 2
Start page 389
End page 403
Total pages 15
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2017
Language eng
Formatted abstract
A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10−8) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10−10) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 04 Mar 2017, 01:00:43 EST by Web Cron on behalf of Learning and Research Services (UQ Library)