Small non-coding RNA expression from anterior cingulate cortex in schizophrenia shows sex specific regulation

Ragan, Chikako, Patel, Kalpana, Edson, Janette, Zhang, Zong-Hong, Gratten, Jacob and Mowry, Bryan (2016) Small non-coding RNA expression from anterior cingulate cortex in schizophrenia shows sex specific regulation. Schizophrenia Research, 183 82-87. doi:10.1016/j.schres.2016.11.024


Author Ragan, Chikako
Patel, Kalpana
Edson, Janette
Zhang, Zong-Hong
Gratten, Jacob
Mowry, Bryan
Title Small non-coding RNA expression from anterior cingulate cortex in schizophrenia shows sex specific regulation
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 1573-2509
0920-9964
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.schres.2016.11.024
Open Access Status Not yet assessed
Volume 183
Start page 82
End page 87
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract MicroRNAs (miRNAs) are known to regulate the expression of genes that are important for brain development and function, but the roles of other classes of small non-coding RNAs (sncRNAs) are less well understood. Additionally, although miRNA expression studies have been conducted in post-mortem brain samples from schizophrenia (SCZ) patients, other classes of sncRNAs are yet to be investigated in SCZ. We profiled the expression of miRNAs, piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and small nuclear RNAs (snRNAs) in SCZ by applying small RNA sequencing (RNA-Seq) to sncRNA isolated from post-mortem anterior cingulate cortex (ACC) of SCZ-affected individuals (n = 22) and matched controls (n = 22). We identified about onethird of annotated miRNAs, one-quarter of snoRNAs and a small proportion of piRNAs and snRNAs. No sncRNAs were significantly differentially expressed between SCZ and controls, but there was evidence for an interaction between disease status and sex on the expression level of a number of miRNAs and snoRNAs. Many of these transcripts exhibited differential expression between male and female cases, and/or between female cases and controls, suggesting sex based dysregulation in ACC of SCZ. These findings require replication in an independent sample, but our study provides further insights into the potential involvement of sncRNAs in brain function and SCZ.
Keyword Gene expression
MiRNAs
Postmortem brain study
RNA-Seq
Schizophrenia
Small non-coding RNAs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
UQ Diamantina Institute Publications
 
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