Review: Placental derived biomarkers of pregnancy disorders

Cuffe, James S. M., Holland, Olivia, Salomon, Carlos, Rice, Gregory E. and Perkins, Anthony V. (2017) Review: Placental derived biomarkers of pregnancy disorders. Placenta, 54 104-110. doi:10.1016/j.placenta.2017.01.119

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Author Cuffe, James S. M.
Holland, Olivia
Salomon, Carlos
Rice, Gregory E.
Perkins, Anthony V.
Title Review: Placental derived biomarkers of pregnancy disorders
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2017-01-16
Sub-type Article (original research)
DOI 10.1016/j.placenta.2017.01.119
Open Access Status File (Author Post-print)
Volume 54
Start page 104
End page 110
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Pregnancy is one of the greatest physiological challenges that a women can experience. The physiological adaptations that accompany pregnancy may increase the risk of developing a number of disorders that can lead to both acute and chronic physiological outcomes. In addition, fetal development may be impaired and, if the fetus survives, the child may be at an increased risk of disease throughout life. Pregnancy disorders are poorly predicted by traditional risk factors and maternal history alone. The identification of biomarkers that can predict incidence and severity of disease would allow for improved and targeted prophylactic therapies to prevent adverse maternal and fetal outcomes. Many of these pregnancy disorders, including preeclampsia, intrauterine growth restriction, gestational diabetes mellitus and preterm birth are known to be regulated at least in part by poor trophoblast invasion and/or dysregulated placental function. Cellular stress within the placenta increases the release of a number of factors into the maternal circulation. While many of these factors minimally impact maternal biology, others affect key physiological systems and contribute to disease. Importantly, these factors may be detected in physiological fluids and have predicative capacity making them ideal candidates as biomarkers of pregnancy disorders. This review will discuss what is known about these placental derived biomarkers of pregnancy disorders and highlight potential clinical opportunities for disease prediction and diagnosis.
Keyword Bioactive peptide
Cell stress marker
Oxidative stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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