Rise in invasive serogroup W meningococcal disease in Australia 2013-2015

Martin, Nicolee V., Ong, Katherine S., Howden, Benjamin P., Lahra, Monica M., Lambert, Stephen B., Beard, Frank H., Dowse, Gary K. and Saul, Nathan (2016) Rise in invasive serogroup W meningococcal disease in Australia 2013-2015. Communicable Diseases Intelligence Quarterly Report, 40 4: E454-E459.

Author Martin, Nicolee V.
Ong, Katherine S.
Howden, Benjamin P.
Lahra, Monica M.
Lambert, Stephen B.
Beard, Frank H.
Dowse, Gary K.
Saul, Nathan
Title Rise in invasive serogroup W meningococcal disease in Australia 2013-2015
Journal name Communicable Diseases Intelligence Quarterly Report   Check publisher's open access policy
ISSN 1447-4514
Publication date 2016-12-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 40
Issue 4
Start page E454
End page E459
Total pages 6
Place of publication Canberra, ACT, Australia
Publisher Australian Government. Department of Health and Ageing
Language eng
Abstract Since 2013, there has been an increase in the number of notified cases of invasive meningococcal disease (IMD) due to serogroup W (MenW) in Australia. In response to this observed increase, the Communicable Diseases Network Australia convened a working group in 2015 to collate and analyse the epidemiology of MenW disease nationally. Enhanced surveillance data collected by jurisdictions were collated and analysed, and whole genome sequencing (WGS) of MenW isolates assessed the genomic relatedness of strains between 2012 and 2015. This report describes that epidemiology. Since 2013, the incidence and proportion of MenW has increased in Australia, rising from an average of 2% of all IMD cases annually (range 0% to 5%) between 1991 and 2012; to 8% (12/149) of cases in 2013, 10% (17/169) in 2014, and 19% (34/182) in 2015. Victoria has been the main affected state, with 50% (17/34) of national cases in 2015. MenW has affected older populations, with a median age between 2003 and 2015 being 44 years. During this period, case fatality was 10.7% (17/159), 2.3 times higher than for all IMD serogroups combined (4.7%, 173/3720). There were 7 deaths due to MenW in 2015 (CFR 21%). WGS has found the majority of Australian isolates cluster within a group of W:P1.5,2:F1-1:ST11 isolates from the United Kingdom and South America, regions where rapid spread and endemic transmission has occurred since 2009. The recent increase in incidence of MenW in Australia is evolving and is being closely monitored. Lessons learned from the international experience will be important in informing the public health response.
Keyword Meningococcal disease
Neisseria meningitidis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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