Concordance of 18F-FDG PET uptake in tumor and normal tissues on PET/MRI and PET/CT

Law, W. P., Maggacis, N., Jeavons, S. J. and Miles, K. A. (2017) Concordance of 18F-FDG PET uptake in tumor and normal tissues on PET/MRI and PET/CT. Clinical Nuclear Medicine, 42 3: 180-186. doi:10.1097/RLU.0000000000001514


Author Law, W. P.
Maggacis, N.
Jeavons, S. J.
Miles, K. A.
Title Concordance of 18F-FDG PET uptake in tumor and normal tissues on PET/MRI and PET/CT
Journal name Clinical Nuclear Medicine   Check publisher's open access policy
ISSN 1536-0229
0363-9762
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1097/RLU.0000000000001514
Open Access Status Not yet assessed
Volume 42
Issue 3
Start page 180
End page 186
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
Abstract Aim The aim of this study was to assess the concordance of PET measurements of F-FDG uptake in tumor and normal tissues obtained on Australia's first clinical PET/MRI scanner in comparison to PET/CT, with comparison against published data. Methods One hundred subjects were prospectively recruited from an unselected, heterogeneous group of cancer patients to undergo F-FDG PET/CT and PET/MRI on the same day. SUVs of physiological regions and tumor tissues obtained by PET/MRI and PET/CT were compared and benchmarked against existing published data. Physiological activity was measured in the thoracic aorta and right lobe of the liver. Tumor SUVs were analyzed by cancer type, body region, and a combined group of all lesions. Results There was an excellent correlation between SUV measurements in tumor lesions obtained by PET/MRI and PET/CT, across all body regions and in all tumor types studied. There was a less robust correlation for SUVs measured in areas of physiological activity, but the level of agreement still fell within 2 SDs of mean. Data from this study showed comparable or smaller systemic biases and narrower confidence limits than existing studies in the literature comparing SUVs from PET/MRI and PET/CT. Conclusions F-FDG PET/MRI appears promising as an adjunct or alternative to PET/CT for quantitative evaluation in oncology, independent of body region and tumor type, across a wide range of SUVs.
Formatted abstract
Aim: The aim of this study was to assess the concordance of PET measurements of 18F-FDG uptake in tumor and normal tissues obtained on Australia's first clinical PET/MRI scanner in comparison to PET/CT, with comparison against published data.

Methods: One hundred subjects were prospectively recruited from an unselected, heterogeneous group of cancer patients to undergo 18F-FDG PET/CT and PET/MRI on the same day. SUVs of physiological regions and tumor tissues obtained by PET/MRI and PET/CT were compared and benchmarked against existing published data. Physiological activity was measured in the thoracic aorta and right lobe of the liver. Tumor SUVs were analyzed by cancer type, body region, and a combined group of all lesions.

Results: There was an excellent correlation between SUV measurements in tumor lesions obtained by PET/MRI and PET/CT, across all body regions and in all tumor types studied. There was a less robust correlation for SUVs measured in areas of physiological activity, but the level of agreement still fell within 2 SDs of mean. Data from this study showed comparable or smaller systemic biases and narrower confidence limits than existing studies in the literature comparing SUVs from PET/MRI and PET/CT.

Conclusions: 18F-FDG PET/MRI appears promising as an adjunct or alternative to PET/CT for quantitative evaluation in oncology, independent of body region and tumor type, across a wide range of SUVs.
Keyword Hybrid imaging
PET/CT
PET/MRI
SUV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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