A time-efficient acquisition protocol for multipurpose diffusion-weighted microstructural imaging at 7 Tesla

Sepehrband, Farshid, O'Brien, Kieran and Barth, Markus (2017) A time-efficient acquisition protocol for multipurpose diffusion-weighted microstructural imaging at 7 Tesla. Magnetic Resonance in Medicine, 78 6: 2170-2184. doi:10.1002/mrm.26608


Author Sepehrband, Farshid
O'Brien, Kieran
Barth, Markus
Title A time-efficient acquisition protocol for multipurpose diffusion-weighted microstructural imaging at 7 Tesla
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 1522-2594
0740-3194
Publication date 2017-02-12
Year available 2017
Sub-type Article (original research)
DOI 10.1002/mrm.26608
Open Access Status File (Author Post-print)
Volume 78
Issue 6
Start page 2170
End page 2184
Total pages 15
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons
Language eng
Abstract Several diffusion-weighted MRI techniques have been developed and validated during the past 2 decades. While offering various neuroanatomical inferences, these techniques differ in their proposed optimal acquisition design, preventing clinicians and researchers benefiting from all potential inference methods, particularly when limited time is available. This study reports an optimal design that enables for a time-efficient diffusion-weighted MRI acquisition scheme at 7 Tesla. The primary audience of this article is the typical end user, interested in diffusion-weighted microstructural imaging at 7 Tesla.

We tested b-values in the range of 700 to 3000 s/mm(2) with different number of angular diffusion-encoding samples, against a data-driven "gold standard."

The suggested design is a protocol with b-values of 1000 and 2500 s/mm(2) , with 25 and 50 samples, uniformly distributed over two shells. We also report a range of protocols in which the results of fitting microstructural models to the diffusion-weighted data had high correlation with the gold standard.

We estimated minimum acquisition requirements that enable diffusion tensor imaging, higher angular resolution diffusion-weighted imaging, neurite orientation dispersion, and density imaging and white matter tract integrity across whole brain with isotropic resolution of 1.8 mm in less than 11 min. Magn Reson Med 78:2170-2184, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Keyword Diffusion-weighted MRI
Minimum requirement
Optimal acquisition range
7 Tesla
NODDI
DTI
CSD
WMTI
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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