The structure of integrin α1I domain in complex with a collagen-mimetic peptide

Chin, Yanni K. -Y., Headey, Stephen J., Mohanty, Biswaranjan, Patil, Rahul, McEwan, Paul A., Swarbrick, James D., Mulhern, Terrence D., Emsley, Jonas, Simpson, Jamie S. and Scanlon, Martin J. (2013) The structure of integrin α1I domain in complex with a collagen-mimetic peptide. Journal of Biological Chemistry, 288 52: 36796-36809. doi:10.1074/jbc.M113.480251

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Author Chin, Yanni K. -Y.
Headey, Stephen J.
Mohanty, Biswaranjan
Patil, Rahul
McEwan, Paul A.
Swarbrick, James D.
Mulhern, Terrence D.
Emsley, Jonas
Simpson, Jamie S.
Scanlon, Martin J.
Title The structure of integrin α1I domain in complex with a collagen-mimetic peptide
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
1083-351X
Publication date 2013-12-01
Sub-type Article (original research)
DOI 10.1074/jbc.M113.480251
Open Access Status File (Publisher version)
Volume 288
Issue 52
Start page 36796
End page 36809
Total pages 14
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Formatted abstract
Background: Collagen-binding integrins bind differentially to different types of collagen.

Results: The solution structure of integrin α1I domain in complex with a collagen-mimetic peptide was determined.

Conclusion: Integrin α1I domain binds collagen in a distinct orientation compared with α2I, but the signal transduction mechanisms appear to be conserved.

Significance: Understanding the collagen binding specificity of integrins might enable their selective modulation in disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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