Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain

Wu, Tong, Grandjean, Joanes, Bosshard, Simone C., Rudin, Markus, Reutens, David and Jiang, Tianzi (2017) Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain. NeuroImage, 149 190-199. doi:10.1016/j.neuroimage.2017.01.074

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Author Wu, Tong
Grandjean, Joanes
Bosshard, Simone C.
Rudin, Markus
Reutens, David
Jiang, Tianzi
Title Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
Publication date 2017-04-01
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2017.01.074
Open Access Status File (Author Post-print)
Volume 149
Start page 190
End page 199
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2808 Neurology
2805 Cognitive Neuroscience
Abstract Studies in mice using resting-state functional magnetic resonance imaging (rs-fMRI) have provided opportunities to investigate the effects of pharmacological manipulations on brain function and map the phenotypes of mouse models of human brain disorders. Mouse rs-fMRI is typically performed under anaesthesia, which induces both regional suppression of brain activity and disruption of large-scale neural networks. Previous comparative studies using rodents investigating various drug effects on long-distance functional connectivity (FC) have reported agent-specific FC patterns, however, effects of regional suppression are sparsely explored. Here we examined changes in regional connectivity under six different anaesthesia conditions using mouse rs-fMRI with the goal of refining the framework of understanding the brain activation under anaesthesia at a local level. Regional homogeneity (ReHo) was used to map local synchronization in the brain, followed by analysis of several brain areas based on ReHo maps. The results revealed high local coherence in most brain areas. The primary somatosensory cortex and caudate-putamen showed agent-specific properties. Lower local coherence in the cingulate cortex was observed under medetomidine, particularly when compared to the combination of medetomidine and isoflurane. The thalamus was associated with retained local coherence across anaesthetic levels and multiple nuclei. These results show that anaesthesia induced by the investigated anaesthetics through different molecular targets promote agent-specific regional connectivity. In addition, ReHo is a data-driven method with minimum user interaction, easy to use and fast to compute. Given that examination of the brain at a local level is widely applied in human rs-fMRI studies, our results show its sensitivity to extract information on varied neuronal activity under six different regimens relevant to mouse functional imaging. These results, therefore, will inform future rs-fMRI studies on mice and the type of anaesthetic agent used, and will help to bridge observations between this burgeoning research field and ongoing human research across analytical scales.
Keyword Anaesthesia
Regional homogeneity
Resting state fMRI
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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