Measuring neuroplasticity associated with cerebral palsy rehabilitation: an MRI based power analysis

Reid, Lee B., Pagnozzi, Alex M., Fiori, Simona, Boyd, Roslyn N., Dowson, Nicholas and Rose, Stephen E. (2017) Measuring neuroplasticity associated with cerebral palsy rehabilitation: an MRI based power analysis. International Journal of Developmental Neuroscience, 58 17-25. doi:10.1016/j.ijdevneu.2017.01.010

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ482452_OA.pdf Full text (open access) application/pdf 2.03MB 0

Author Reid, Lee B.
Pagnozzi, Alex M.
Fiori, Simona
Boyd, Roslyn N.
Dowson, Nicholas
Rose, Stephen E.
Title Measuring neuroplasticity associated with cerebral palsy rehabilitation: an MRI based power analysis
Journal name International Journal of Developmental Neuroscience   Check publisher's open access policy
ISSN 1873-474X
Publication date 2017-05-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.ijdevneu.2017.01.010
Open Access Status File (Author Post-print)
Volume 58
Start page 17
End page 25
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2806 Developmental Neuroscience
1309 Developmental Biology
Abstract Researchers in the field of child neurology are increasingly looking to supplement clinical trials of motor rehabilitation with neuroimaging in order to better understand the relationship between behavioural training, brain changes, and clinical improvements. Randomised controlled trials are typically accompanied by sample size calculations to detect clinical improvements but, despite the large cost of neuroimaging, not equivalent calculations for concurrently acquired imaging neuroimaging measures of changes in response to intervention. To aid in this regard, a power analysis was conducted for two measures of brain changes that may be indexed in a trial of rehabilitative therapy for cerebral palsy: cortical thickness of the impaired primary sensorimotor cortex, and fractional anisotropy of the impaired, delineated corticospinal tract. Power for measuring fractional anisotropy was assessed for both region-of-interest-seeded and fMRI-seeded diffusion tractography. Taking into account practical limitations, as well as data loss due to behavioural and image-processing issues, estimated required participant numbers were 101, 128 and 59 for cortical thickness, region-of-interest-based tractography, and fMRI-seeded tractography, respectively. These numbers are not adjusted for study attrition. Although these participant numbers may be out of reach of many trials, several options are available to improve statistical power, including careful preparation of participants for scanning using mock simulators, careful consideration of image processing options, and enrolment of as homogeneous a cohort as possible. This work suggests that smaller and moderate sized studies give genuine consideration to harmonising scanning protocols between groups to allow the pooling of data.
Keyword Cerebral palsy
Diffusion MRI
Functional MRI
Multimodal MRI
Randomised-controlled-trial power
Statistical power
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 28 Feb 2017, 00:20:24 EST by Web Cron on behalf of Learning and Research Services (UQ Library)