The molecular epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in Australia: a nationwide cross-sectional study, 2012

Trembizki, Ella, Wand, Handan, Donovan, Basil, Chen, Marcus, Fairley, Christopher K., Freeman, Kevin, Guy, Rebecca, Kaldor, John M., Lahra, Monica M., Lawrence, Andrew, Lau, Colleen, Pearson, Julie, Regan, David G., Ryder, Nathan, Smith, Helen, Stevens, Kerrie, Su, Jiunn-Yih, Ward, James and Whiley, David M. (2016) The molecular epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in Australia: a nationwide cross-sectional study, 2012. Clinical Infectious Diseases, 63 12: 1591-1598. doi:10.1093/cid/ciw648


Author Trembizki, Ella
Wand, Handan
Donovan, Basil
Chen, Marcus
Fairley, Christopher K.
Freeman, Kevin
Guy, Rebecca
Kaldor, John M.
Lahra, Monica M.
Lawrence, Andrew
Lau, Colleen
Pearson, Julie
Regan, David G.
Ryder, Nathan
Smith, Helen
Stevens, Kerrie
Su, Jiunn-Yih
Ward, James
Whiley, David M.
Title The molecular epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in Australia: a nationwide cross-sectional study, 2012
Formatted title
The molecular epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in Australia: a nationwide cross-sectional study, 2012
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1058-4838
1537-6591
Publication date 2016-12-15
Sub-type Article (original research)
DOI 10.1093/cid/ciw648
Open Access Status Not yet assessed
Volume 63
Issue 12
Start page 1591
End page 1598
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2017
Language eng
Formatted abstract
Background: Antimicrobial resistance (AMR) by Neisseria gonorrhoeae is considered a serious global threat.

Methods: In this nationwide study, we used MassARRAY iPLEX genotyping technology to examine the epidemiology of N. gonorrhoeae and associated AMR in the Australian population. All available N. gonorrhoeae isolates (n = 2452) received from Australian reference laboratories from January to June 2012 were included in the study. Genotypic data were combined with phenotypic AMR information to define strain types.

Results: A total of 270 distinct strain types were observed. The 40 most common strain types accounted for over 80% of isolates, and the 10 most common strain types accounted for almost half of all isolates. The high male to female ratios (>94% male) suggested that at least 22 of the top 40 strain types were primarily circulating within networks of men who have sex with men (MSM). Particular strain types were also concentrated among females: two strain types accounted for 37.5% of all isolates from females. Isolates harbouring the mosaic penicillin binding protein 2 (PBP2)—considered a key mechanism for cephalosporin resistance—comprised 8.9% of all N. gonorrhoeae isolates and were primarily observed in males (95%).

Conclusions: This large scale epidemiological investigation demonstrated that N. gonorrhoeae infections are dominated by relatively few strain types. The commonest strain types were concentrated in MSM in urban areas and Indigenous heterosexuals in remote areas, and we were able to confirm a resurgent epidemic in heterosexual networks in urban areas. The prevalence of mosaic PBP2 harboring N. gonorrhoeae strains highlight the ability for new N. gonorrhoeae strains to spread and become established across populations.
Keyword Gonorrhea
Typing
Resistance
Molecular
Surveillance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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Child Health Research Centre Publications
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