Cytokine receptors

Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2016). Cytokine receptors. In Antonino Belfiore and Derek LeRoith (Ed.), Endocrinology: principles of endocrinology and hormone action (pp. 1-29) Amsterdam, The Netherlands: Springer. doi:10.1007/978-3-319-27318-1_8-1


Author Brooks, Andrew J.
Dehkhoda, Farhad
Kragelund, Birthe
Title of chapter Cytokine receptors
Title of book Endocrinology: principles of endocrinology and hormone action
Place of Publication Amsterdam, The Netherlands
Publisher Springer
Publication Year 2016
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1007/978-3-319-27318-1_8-1
Open Access Status Not yet assessed
Series Endocrinology
ISBN 9783319273181
ISSN 2510-1927
Editor Antonino Belfiore
Derek LeRoith
Start page 1
End page 29
Total pages 29
Collection year 2017
Language eng
Abstract/Summary Cytokine receptors initiate intracellular signalling that regulate a diverse range of biological and medically important functions including metabolism control, neural stem cell activation, inflammatory responses, bone development, as well as blood cell and immune cell development and growth. The unifying feature of these receptors is their ability to activate the JAK-STAT pathway, however they are grouped into two structurally related classes, known as class I and class II. Class I cytokine receptors has over 30 members including receptors for erythropoietin (EPO), prolactin (PRL), growth hormone (GH), thrombopoietin (TPO), leptin, (LEP), granulocyte-macrophage colony-stimulating factor (GM-CSF), leukaemia inhibitory factor (LIF), interleukin-3 (IL-3), IL-5, IL-6, and IL-7. The Class I cytokine receptor family includes the interferon receptors, IL-10 receptor, and number of more recently discovered cytokine receptors for IL-19, IL-20, IL-22, IL-24, IL-26, and IL-29. This chapter will review the structure, activation mechanism, and signalling of cytokine receptors.
Keyword Cytokine receptors
JAK
STATs
Growth hormone receptor
Prolactin receptor
Class I cytokine receptors
Class II cytokine receptors
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 24 Feb 2017, 12:53:14 EST by Andrew Brooks on behalf of Institute for Molecular Bioscience