Prevalence and patterns of congenital heart diseases in Africa: a systematic review and meta-analysis protocol

Tankeu, Aurel T., Bigna, Jean Joel R., Nansseu, Jobert Richie N., Aminde, Leopold Ndemnge, Danwang, Celestin, Temgoua, Mazou N. and Noubiap, Jean Jacques N. (2017) Prevalence and patterns of congenital heart diseases in Africa: a systematic review and meta-analysis protocol. BMJ Open, 7 2: e015633. doi:10.1136/bmjopen-2016-015633

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Author Tankeu, Aurel T.
Bigna, Jean Joel R.
Nansseu, Jobert Richie N.
Aminde, Leopold Ndemnge
Danwang, Celestin
Temgoua, Mazou N.
Noubiap, Jean Jacques N.
Title Prevalence and patterns of congenital heart diseases in Africa: a systematic review and meta-analysis protocol
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2017-01-19
Year available 2017
Sub-type Article (original research)
DOI 10.1136/bmjopen-2016-015633
Open Access Status DOI
Volume 7
Issue 2
Start page e015633
Total pages 5
Place of publication London, United Kingdom
Publisher BMJ Group
Language eng
Subject 2700 Medicine
Abstract Introduction: Congenital heart diseases (CHD) are common causes of cardiovascular morbidity and mortality among young children and adolescents living in Africa. Accurate epidemiological data are needed in order to evaluate and improve preventive strategies. This review aims to determine the prevalence of CHD and their main patterns in Africa. Methods and analysis: This systematic review and meta-analysis will include cross-sectional, case-control and cohort studies of populations residing inside African countries, which have reported the prevalence of CHD, confirmed by an echocardiographic examination and/or describing different patterns of these abnormalities in Africa. Relevant abstracts published without language restriction from 1 January 1986 to 31 December 2016 will be searched in PubMed, Exerpta Medica Database and online African journals as well as references of included articles and relevant reviews. Two review authors will independently screen, select studies, extract data and assess the risk of bias in each study. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence of CHD across studies. Clinical and statistical heterogeneity will be assessed, and we will pool studies judged to be clinically homogeneous. On the other hand, statistical heterogeneity will be evaluated by the ÷2 test on Cochrane's Q statistic. Funnel-plots analysis and Egger's test will be used to detect publication bias. Results will be presented by geographic region (central, eastern, northern, southern and western Africa). Ethics and dissemination: The current study will be based on published data, and thus ethical approval is not required. This systematic review and meta-analysis is expected to serve as a base which could help in estimating and evaluating the burden of these abnormalities on the African continent. The final report of this study will be published in a peer-reviewed journal. Trial registration number: PROSPERO CRD42016052880.
Formatted abstract
Introduction Congenital heart diseases (CHD) are common causes of cardiovascular morbidity and mortality among young children and adolescents living in Africa. Accurate epidemiological data are needed in order to evaluate and improve preventive strategies. This review aims to determine the prevalence of CHD and their main patterns in Africa.

Methods and analysis This systematic review and meta-analysis will include cross-sectional, case–control and cohort studies of populations residing inside African countries, which have reported the prevalence of CHD, confirmed by an echocardiographic examination and/or describing different patterns of these abnormalities in Africa. Relevant abstracts published without language restriction from 1 January 1986 to 31 December 2016 will be searched in PubMed, Exerpta Medica Database and online African journals as well as references of included articles and relevant reviews. Two review authors will independently screen, select studies, extract data and assess the risk of bias in each study. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate of the prevalence of CHD across studies. Clinical and statistical heterogeneity will be assessed, and we will pool studies judged to be clinically homogeneous. On the other hand, statistical heterogeneity will be evaluated by the χ2 test on Cochrane's Q statistic. Funnel-plots analysis and Egger's test will be used to detect publication bias. Results will be presented by geographic region (central, eastern, northern, southern and western Africa).

Ethics and dissemination The current study will be based on published data, and thus ethical approval is not required. This systematic review and meta-analysis is expected to serve as a base which could help in estimating and evaluating the burden of these abnormalities on the African continent. The final report of this study will be published in a peer-reviewed journal.
Keyword Africa
Heart defects
cardiac malformation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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Created: Tue, 21 Feb 2017, 12:14:51 EST by Leopold Aminde on behalf of School of Public Health