Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles

Kar, Subhabrata, Tillu, Vikas A., Meena, Shiv Charan and Pande, Abhay H. (2011) Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles. Chemistry and Physics of Lipids, 164 1: 54-61. doi:10.1016/j.chemphyslip.2010.10.006


Author Kar, Subhabrata
Tillu, Vikas A.
Meena, Shiv Charan
Pande, Abhay H.
Title Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles
Journal name Chemistry and Physics of Lipids   Check publisher's open access policy
ISSN 0009-3084
1873-2941
Publication date 2011-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.chemphyslip.2010.10.006
Open Access Status Not yet assessed
Volume 164
Issue 1
Start page 54
End page 61
Total pages 8
Place of publication Shannon, Clare, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Oxidation of glycerophospholipids results in the formation of large variety of oxidized phospholipid products that differs significantly in their chemical compositions and molecular structures. Biological activities of these oxidized products also differ considerably. Here we report the comparisons of the physicochemical properties of non-oxidized phospholipid particle containing two closely related tOx-PLs: 1-palmitoyl-2-(5-keto-6-octendioyl)-sn-glycero-3-phosphocholine (KOdiA-PC) and 1-palmitoyl-2-(9-keto-10-dodecendioyl)-sn-glycero-3-phosphocholine (KDdiA-PC). DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) was used as a model membrane non-oxidized phospholipid. Physicochemical properties of the lipid particles were characterized by using fluorescence spectroscopy, native polyacrylamide gel and agarose gel electrophoresis. Our result shows that the presence of closely related tOx-PLs, which differ only in the chemical composition of the oxidized fatty acyl chains at the sn-2 position, exerts considerably different effect on the physicochemical properties of non-oxidized phospholipid particles containing them.
Keyword Anisotropy
Critical micellar concentration
Dipole potential
Generalized polarization
KDdiA-PC
KOdiA-PC
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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