Retromer’s role in endosomal trafficking and impaired function in neurodegenerative diseases

Follett, Jordan, Bugarcic, Andrea, Collins, Brett M. and Teasdale, Rohan D. (2017) Retromer’s role in endosomal trafficking and impaired function in neurodegenerative diseases. Current Protein and Peptide Science, 18 7: 687-701. doi:10.2174/1389203717666160311121246


Author Follett, Jordan
Bugarcic, Andrea
Collins, Brett M.
Teasdale, Rohan D.
Title Retromer’s role in endosomal trafficking and impaired function in neurodegenerative diseases
Journal name Current Protein and Peptide Science   Check publisher's open access policy
ISSN 1875-5550
1389-2037
Publication date 2017-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/1389203717666160311121246
Open Access Status Not yet assessed
Volume 18
Issue 7
Start page 687
End page 701
Total pages 15
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35 - that were identified over a decade ago in Saccharomyces cerevisiae (S. cerevisiae). Initially, mammalian retromer was shown to sort transmembrane proteins from the endosome to the trans-Golgi network (TGN), though recent work has identified a critical role for retromer in multiple trafficking pathways, including recycling to the plasma membrane and regulation of cell polarity. In recent years, genetic, cellular, pharmacological and animal model studies have identified retromer and its interacting proteins as being linked to familial forms of neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s (PD). Here, this commentary will summarize recently identified point mutations in retromer linked to PD, and explore the molecular functions of retromer that may be relevant to disease progression.
Keyword Cathepsin D
Endosome
Parkinson’s disease
Retromer
Sorting nexin
Vps35 p.D620N
Vps35 p.R524W
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 21 Feb 2017, 00:20:20 EST by Web Cron on behalf of Learning and Research Services (UQ Library)