A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested

Bambling, Matthew, Edwards, Sophie C., Hall, Sean and Vitetta, Luis (2017) A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested. Inflammopharmacology, 25 2: 1-4. doi:10.1007/s10787-017-0311-x


Author Bambling, Matthew
Edwards, Sophie C.
Hall, Sean
Vitetta, Luis
Title A combination of probiotics and magnesium orotate attenuate depression in a small SSRI resistant cohort: an intestinal anti-inflammatory response is suggested
Journal name Inflammopharmacology   Check publisher's open access policy
ISSN 1568-5608
0925-4692
Publication date 2017-02-02
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1007/s10787-017-0311-x
Open Access Status Not yet assessed
Volume 25
Issue 2
Start page 1
End page 4
Total pages 4
Place of publication Basel, Switzerland
Publisher Springer Basel AG
Language eng
Subject 2403 Immunology
3004 Pharmacology
2736 Pharmacology (medical)
Abstract Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0.001) with all but 4 participants experiencing a benefit. An intestinal anti-inflammatory response was suggested. At 16-weeks follow-up while still on SSRI medications, the group had relapsed after cessation of the test intervention.
Formatted abstract
Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0.001) with all but 4 participants experiencing a benefit. An intestinal anti-inflammatory response was suggested. At 16-weeks follow-up while still on SSRI medications, the group had relapsed after cessation of the test intervention.
Keyword Depression
Inflammation
Intestinal dysbiosis
Magnesium orotate
Probiotics
SSRI
Treatment resistance
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: HERDC Pre-Audit
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