Reduced activity of SRY and its target enhancer Sox9-TESCO in a mouse species with X∗Y sex reversal

Zhao, Liang, Quinn, Alexander, Ng, Ee Ting, Veyrunes, Frederic and Koopman, Peter (2017) Reduced activity of SRY and its target enhancer Sox9-TESCO in a mouse species with X∗Y sex reversal. Scientific Reports, 7 . doi:10.1038/srep41378

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Author Zhao, Liang
Quinn, Alexander
Ng, Ee Ting
Veyrunes, Frederic
Koopman, Peter
Title Reduced activity of SRY and its target enhancer Sox9-TESCO in a mouse species with X∗Y sex reversal
Formatted title
Reduced activity of SRY and its target enhancer Sox9-TESCO in a mouse species with X∗Y sex reversal
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-02-03
Year available 2017
Sub-type Article (original research)
DOI 10.1038/srep41378
Open Access Status DOI
Volume 7
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X∗), yielding X∗Y females. We hypothesized that X∗Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we show that neither M. minutoides SRY nor its target, the Sox9-TESCO enhancer, had appreciable transcriptional activity in in vitro assays, correlating with sequence degradation compared to Mus musculus counterparts. However, M. minutoides SRY activated its cognate TESCO to a moderate degree, and can clearly engage the male pathway in M. minutoides in the wild, indicating that SRY and TESCO may have co-evolved in M. minutoides to retain function above a threshold level. We suggest that weakening of the SRY/TESCO nexus may have facilitated the rise and spread of a variant X∗ chromosome carrying female-inducing modifier gene(s).
Keyword Differentiation
Evolutionary biology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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