Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy

Wengstrom, Y., Bolam, K. A., Mijwel, S., Sundberg, C. J., Backman, M., Browall, M., Norrbom, J. and Rundqvist, H. (2017) Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy. BMC Cancer, 17 1: . doi:10.1186/s12885-017-3079-x

Author Wengstrom, Y.
Bolam, K. A.
Mijwel, S.
Sundberg, C. J.
Backman, M.
Browall, M.
Norrbom, J.
Rundqvist, H.
Title Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2017-02-06
Sub-type Article (original research)
DOI 10.1186/s12885-017-3079-x
Open Access Status DOI
Volume 17
Issue 1
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve physical function as well as quality of life. The primary aim of the study is to investigate and compare the effects of two different exercise regimens on the primary outcome cancer-related fatigue and the secondary outcomes muscle strength, function and structure, cardiovascular fitness, systemic inflammation, skeletal muscle gene activity, health related quality of life, pain, disease and treatment-related symptoms in women with breast cancer receiving chemotherapy. The second aim is to examine if any effects are sustained 1, 2, and 5 years following the completion of the intervention and to monitor return to work, recurrence and survival. The third aim of the study is to examine the effect of attendance and adherence rates on the effects of the exercise programme.

Methods: This study is a randomised controlled trial including 240 women with breast cancer receiving chemotherapy in Stockholm, Sweden. The participants are randomly allocated to either: group 1: Aerobic training, group 2: Combined resistance and aerobic training, or group 3: usual care (control group). During the 5-year follow-up period, participants in the exercise groups will receive a physical activity prescription. Measurements for endpoints will take place at baseline, after 16 weeks (end of intervention) as well as after 1, 2 and 5 years.

Discussion: This randomised controlled trial will generate substantial information regarding the effects of different types of exercise on the health of patients with breast cancer undergoing chemotherapy. We expect that dissemination of the knowledge gained from this study will contribute to developing effective long term strategies to improve the physical and psychosocial health of breast cancer survivors.

Trial registration: OptiTrain - Optimal Training Women with Breast Cancer (OptiTrain), NCT02522260 ; Registration: June 9, 2015, Last updated version Feb 29, 2016. Retrospectively registered.
Keyword Chemotherapy
Exercise intervention
Patients with breast cancer
Skeletal muscle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
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