Cyclotide structure and function: the role of membrane binding and permeation

Troeira Henriques, Sonia and Craik, David J. (2017) Cyclotide structure and function: the role of membrane binding and permeation. Biochemistry, 56 5: 669-682. doi:10.1021/acs.biochem.6b01212


Author Troeira Henriques, Sonia
Craik, David J.
Title Cyclotide structure and function: the role of membrane binding and permeation
Journal name Biochemistry   Check publisher's open access policy
ISSN 1520-4995
0006-2960
Publication date 2017-02-07
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1021/acs.biochem.6b01212
Open Access Status Not yet assessed
Volume 56
Issue 5
Start page 669
End page 682
Total pages 14
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract There is growing interest in the use of peptides as therapeutic drugs and, in particular, in the potential of cyclotides, a family of cyclic peptides with remarkable stability and amenability to sequence engineering, as scaffolds in drug design. As well as having an ultrastable structure, many natural cyclotides have intrinsic biological activities with potential pharmaceutical or agricultural applications. Some cyclotides also have the ability to cross membrane barriers and to enter into cells; in particular, cyclotides that belong to the Möbius and bracelet subfamilies have been found to harbor lipid-binding domains, which allow for the specific recognition of phosphatidylethanolamine phospholipids in biological membranes. This lipid selectivity is intimately correlated with the highly conserved three-dimensional structures of cyclotides and is important for their reported biological properties and cell penetration ability. The membrane binding features of Möbius and bracelet cyclotides contrast with the lack of membrane binding of trypsin inhibitor cyclotides, which have physicochemical properties and bioactivities different from those of the other two subfamilies of cyclotides but are also able to enter cells. This review discusses the structures of cyclotides with regard to their myriad of biological activities and describes the role of membrane binding in their functions and ability to enter cells.
Keyword Biochemistry & Molecular Biology
Biochemistry & Molecular Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP150100443
APP1084965
FT150100398
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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