Hydrogels with lotus leaf topography: investigating surface properties and cell adhesion

Santander-Borrego, Miriem, Taran, Elena, Shadforth, Audra M. A., Whittaker, Andrew K., Chirila, Traian V. and Blakey, Idriss (2017) Hydrogels with lotus leaf topography: investigating surface properties and cell adhesion. Langmuir, 33 2: 485-493. doi:10.1021/acs.langmuir.6b03547


Author Santander-Borrego, Miriem
Taran, Elena
Shadforth, Audra M. A.
Whittaker, Andrew K.
Chirila, Traian V.
Blakey, Idriss
Title Hydrogels with lotus leaf topography: investigating surface properties and cell adhesion
Journal name Langmuir   Check publisher's open access policy
ISSN 0743-7463
1520-5827
Publication date 2017-01-17
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.langmuir.6b03547
Open Access Status Not yet assessed
Volume 33
Issue 2
Start page 485
End page 493
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract The interactions of cells with the surface of materials is known to be influenced by a range of factors that include chemistry and roughness; however, it is often difficult to probe these factors individually without also changing the others. Here we investigate the role of roughness on cell adhesion while maintaining the same underlying chemistry. This was achieved by using a polymerization in mold technique to prepare poly(hydroxymethyl methacrylate) hydrogels with either a flat topography or a topography that replicated the microscale features of lotus leaves. These materials were then assessed for cell adhesion, and atomic force microscopy and contact angle analysis were then used to probe the physical reasons for the differing behavior in relation to cell adhesion.
Keyword Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP0878615
FT100100721
LE0775684
Institutional Status UQ

 
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