Current perspectives on left ventricular geometry in systemic hypertension

Oktay, Ahmet Afşin, Lavie, Carl J., Milani, Richard V., Ventura, Hector O., Gilliland, Yvonne E., Shah, Sangeeta and Cash, Michael E. (2016) Current perspectives on left ventricular geometry in systemic hypertension. Progress in Cardiovascular Diseases, 59 3: 235-246. doi:10.1016/j.pcad.2016.09.001

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Author Oktay, Ahmet Afşin
Lavie, Carl J.
Milani, Richard V.
Ventura, Hector O.
Gilliland, Yvonne E.
Shah, Sangeeta
Cash, Michael E.
Title Current perspectives on left ventricular geometry in systemic hypertension
Journal name Progress in Cardiovascular Diseases   Check publisher's open access policy
ISSN 1873-1740
0033-0620
Publication date 2016-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pcad.2016.09.001
Open Access Status File (Author Post-print)
Volume 59
Issue 3
Start page 235
End page 246
Total pages 12
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Collection year 2017
Language eng
Abstract Hypertension (HTN) is a global health problem and a leading risk factor for cardiovascular disease (CVD) morbidity and mortality. The hemodynamic overload from HTN causes left ventricular (LV) remodeling, which usually manifests as distinct alterations in LV geometry, such as concentric remodeling or concentric and eccentric LV hypertrophy (LVH). In addition to being a common target organ response to HTN, LV geometric abnormalities are well-known independent risk factors for CVD. Because of their prognostic implications and quantifiable nature, changes in LV geometric parameters have commonly been included as an outcome in anti-HTN drug trials. The purpose of this paper is to review the relationship between HTN and LV geometric changes with a focus on (1) diagnostic approach, (2) epidemiology, (3) pathophysiology, (4) prognostic effect and (5) LV response to anti-HTN therapy and its impact on CVD risk reduction.
Keyword Anti-hypertension therapy
Hypertension
Left ventricular geometry
Left ventricular hypertrophy
Remodeling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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