A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific Region

Barzi, F., Patel, A., Woodward, M., Lawes, C. M. M., Ohkubo, T., Gu, D., Lam, T. H., Ueshima, H., Pan, W., Suh, I., Rodgers, A., Bennett, D., Parag, V., Xie, J. X., Norton, R. and et al. (2005) A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific Region. Annals of Epidemiology, 15 5: 405-413. doi:10.1016/j.annepidem.2005.01.005

Author Barzi, F.
Patel, A.
Woodward, M.
Lawes, C. M. M.
Ohkubo, T.
Gu, D.
Lam, T. H.
Ueshima, H.
Pan, W.
Suh, I.
Rodgers, A.
Bennett, D.
Parag, V.
Xie, J. X.
Norton, R.
et al.
Title A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific Region
Journal name Annals of Epidemiology   Check publisher's open access policy
ISSN 1047-2797
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1016/j.annepidem.2005.01.005
Open Access Status Not yet assessed
Volume 15
Issue 5
Start page 405
End page 413
Total pages 9
Place of publication New York, U.S.
Publisher Elsevier Science
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Abstract PURPOSE: Many guidelines advocate measurement of total or low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides (TG) to determine treatment recommendations for preventing coronary heart disease (CHD) and cardiovascular disease (CVD). This analysis is a comparison of lipid variables as predictors of cardiovascular disease. METHODS: Hazard ratios for coronary and cardiovascular deaths by fourths of total cholesterol (TC), LDL, HDL, TG, non-HDL, TC/HDL, and TG/HDL values, and for a one standard deviation change in these variables, were derived in an individual participant data meta-analysis of 32 cohort studies conducted in the Asia-Pacific region. The predictive value of each lipid variable was assessed using the likelihood ratio statistic. RESULTS: Adjusting for confounders and regression dilution, each lipid variable had a positive (negative for HDL) log-linear association with fatal CHD and CVD. Individuals in the highest fourth of each lipid variable had approximately twice the risk of CHD compared with those with lowest levels. TG and HDL were each better predictors of CHD and CVD risk compared with TC alone, with test statistics similar to TC/HDL and TG/HDL ratios. Calculated LDL was a relatively poor predictor. CONCLUSIONS: While LDL reduction remains the main target of intervention for lipid-lowering, these data support the potential use of TG or lipid ratios for CHD risk prediction. (c) 2005 Elsevier Inc. All rights reserved.
Keyword Public, Environmental & Occupational Health
Total Cholesterol
Ldl Cholesterol
Hdl Cholesterol
Non-hdl Cholesterol
Lipid Ratios
Cardiovascular Heart Disease
Density-lipoprotein Cholesterol
High-risk Individuals
Secondary Prevention
Regression Dilution
Controlled Trial
Hdl Cholesterol
Relative Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 76 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 79 times in Scopus Article | Citations
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Created: Tue, 14 Aug 2007, 01:11:48 EST