Genital Inflammation and the Risk of HIV Acquisition in Women

Masson L., Passmore J.-A.S., Liebenberg L.J., Werner L., Baxter C., Arnold K.B., Williamson C., Little F., Mansoor L.E., Naranbhai V., Lauffenburger D.A., Ronacher K., Walzl G., Garrett N.J., Williams B.L., Couto-Rodriguez M., Hornig M., Lipkin W.I., Grobler A., Abdool Karim Q. and Abdool Karim S.S. (2015) Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases, 61 2: 260-269. doi:10.1093/cid/civ298

Author Masson L.
Passmore J.-A.S.
Liebenberg L.J.
Werner L.
Baxter C.
Arnold K.B.
Williamson C.
Little F.
Mansoor L.E.
Naranbhai V.
Lauffenburger D.A.
Ronacher K.
Walzl G.
Garrett N.J.
Williams B.L.
Couto-Rodriguez M.
Hornig M.
Lipkin W.I.
Grobler A.
Abdool Karim Q.
Abdool Karim S.S.
Title Genital Inflammation and the Risk of HIV Acquisition in Women
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1537-6591
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/cid/civ298
Open Access Status Not Open Access
Volume 61
Issue 2
Start page 260
End page 269
Total pages 10
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Formatted abstract
Background: Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group.

Methods: Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γinducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial.

Results: HIV seroconversion was associated with raised genital inflammatory cytokines (including chemokines MIP-1α, MIP-1β, and IP-10). The risk of HIV acquisition was significantly higher in women with evidence of genital inflammation, defined by at least 5 of 9 inflammatory cytokines being raised (odds ratio, 3.2;95% confidence interval, 1.3-7.9;P =. 014). Genital cytokine concentrations were persistently raised (for about 1 year before infection), with no readily identifiable cause despite extensive investigation of several potential factors, including sexually transmitted infections and systemic cytokines.

Conclusions: Elevated genital concentrations of HIV target cell-recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.
Keyword Cytokine
Female genital tract
HIV transmission
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FHI 360
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
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