SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice

Zhao, Liang, Arsenault, Michel, Ng, Ee Ting, Longmuss, Enya, Chau, Tevin Chui-Ying, Hartwig, Sunny and Koopman, Peter (2017) SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Developmental Biology, 423 1: 46-56. doi:10.1016/j.ydbio.2017.01.013

Author Zhao, Liang
Arsenault, Michel
Ng, Ee Ting
Longmuss, Enya
Chau, Tevin Chui-Ying
Hartwig, Sunny
Koopman, Peter
Title SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice
Journal name Developmental Biology   Check publisher's open access policy
ISSN 1095-564X
Publication date 2017-01-21
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2017.01.013
Open Access Status Not yet assessed
Volume 423
Issue 1
Start page 46
End page 56
Total pages 11
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
The group C SOX transcription factors SOX4, −11 and −12 play important and mutually overlapping roles in development of a number of organs. Here, we examined the role of SoxC genes during gonadal development in mice. All three genes were expressed in developing gonads of both sexes, predominantly in somatic cells, with Sox4 being most strongly expressed. Sox4 deficiency resulted in elongation of both ovaries and testes, and an increased number of testis cords. While female germ cells entered meiosis normally, male germ cells showed reduced levels of differentiation markers Nanos2 and Dnmt3l and increased levels of pluripotency genes Cripto and Nanog, suggesting that SOX4 may normally act to restrict the pluripotency period of male germ cells and ensure their proper differentiation. Finally, our data reveal that SOX4 (and, to a lesser extent, SOX11 and −12) repressed transcription of the sex-determining gene Sox9 via an upstream testis-specific enhancer core (TESCO) element in fetal gonads, raising the possibility that SOXC proteins may function as transcriptional repressors in a context-dependent manner.
Keyword Gonad development
Sex determination
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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