Review: Placental adaptations to the presence of maternal asthma during pregnancy

Meakin, A. S., Saif, Z., Jones, A. R., Aviles, P. F. V. and Clifton, V. L. (2017) Review: Placental adaptations to the presence of maternal asthma during pregnancy. Placenta, 54 17-23. doi:10.1016/j.placenta.2017.01.123

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Author Meakin, A. S.
Saif, Z.
Jones, A. R.
Aviles, P. F. V.
Clifton, V. L.
Title Review: Placental adaptations to the presence of maternal asthma during pregnancy
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2017-01-21
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.placenta.2017.01.123
Open Access Status File (Author Post-print)
Volume 54
Start page 17
End page 23
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract Asthma is a highly prevalent chronic medical condition affecting an estimated 12% of pregnant, women each year, with prevalence of asthma greatest (up to 16%) among the socially disadvantaged. Maternal asthma is associated with significant perinatal morbidity and mortality including preterm births, neonatal hospitalisations and low birthweight outcomes each year. We have identified that the placenta adapts to the presence of chronic, maternal asthma during pregnancy in a sex specific manner that may confer sex differences in fetal outcome. The male fetus was at greater risk of a poor outcome than a female fetus in the presence of maternal asthma and an acute inflammatory event such as an asthma exacerbation. This review will examine the role of sex specific differences in placental function on fetal growth and survival.
Keyword Asthma
Fetus
Growth
Placenta
Sex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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