A Tol2 gateway-compatible toolbox for the study of the nervous system and neurodegenerative disease

Don, Emily K., Formella, Isabel, Badrock, Andrew P., Hall, Thomas E., Morsch, Marco, Hortle, Elinor, Hogan, Alison, Chow, Sharron, Gwee, Serene S. L., Stoddart, Jack J., Nicholson, Garth , Chung, Roger and Cole, Nicholas J. (2017) A Tol2 gateway-compatible toolbox for the study of the nervous system and neurodegenerative disease. Zebrafish, 14 1: 69-72. doi:10.1089/zeb.2016.1321


Author Don, Emily K.
Formella, Isabel
Badrock, Andrew P.
Hall, Thomas E.
Morsch, Marco
Hortle, Elinor
Hogan, Alison
Chow, Sharron
Gwee, Serene S. L.
Stoddart, Jack J.
Nicholson, Garth
Chung, Roger
Cole, Nicholas J.
Title A Tol2 gateway-compatible toolbox for the study of the nervous system and neurodegenerative disease
Journal name Zebrafish   Check publisher's open access policy
ISSN 1545-8547
1557-8542
Publication date 2017-02-01
Year available 2017
Sub-type Article (original research)
DOI 10.1089/zeb.2016.1321
Open Access Status Not yet assessed
Volume 14
Issue 1
Start page 69
End page 72
Total pages 4
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Language eng
Abstract Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
Keyword Disease model
Neurodegenerative disease
Tol2 gateway
Transgenesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID GIA1409
GNT1034816
DP140103233
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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