The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis

Carbone, Antonino, Gloghini, Annunziata, Caruso, Arnaldo, De Paoli, Paolo and Dolcetti, Riccardo (2017) The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis. International Journal of Cancer, 140 6: 1233-1245. doi:10.1002/ijc.30473


Author Carbone, Antonino
Gloghini, Annunziata
Caruso, Arnaldo
De Paoli, Paolo
Dolcetti, Riccardo
Title The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
0020-7136
Publication date 2017-03-15
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ijc.30473
Open Access Status Not yet assessed
Volume 140
Issue 6
Start page 1233
End page 1245
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2730 Oncology
1306 Cancer Research
Abstract The pathogenesis of classical Hodgkin lymphoma (cHL) is still enigmatic, largely because its tumor cells, the so-called Hodgkin and Reed–Stenberg (HRS) cells, invariably reside in a prominent reactive microenvironment, are rare and therefore difficult to analyze. On the other hand, the broadly investigated cHL-derived cell lines are not unequivocally considered as suitable and representative models for this puzzling disease. Based on current knowledge, it appears that the cross talk between the tumor cells and the reactive infiltrate of the microenvironment is complex and that multiple mechanisms occur, making cHL a very heterogeneous disease. In 20–40% of cHL cases, HRS cells carry a monoclonal infection by Epstein Barr virus (EBV), which is considered a tumor-initiating factor. In these cases, EBV shows a latency type II infection pattern with the expression of latent membrane protein-1 (LMP-1), a viral oncoprotein that mimics CD40 activation. This scenario is particularly intriguing for the pathogenesis of cHL arising in HIV-infected patients, which, for still obscure reasons, is invariably EBV-associated with LMP-1 expression in HRS cells. Recent evidences are consistent with the occurrence of different pathogenic pathways variably triggered by virus infections (EBV and HIV), genetic alterations, and interactions with critical microenvironmental components. This review focuses on the different microenvironmental niches that characterize cHL of the general population as well as cases of HIV-infected patients. A more comprehensive understanding of the complex interplay existing between HRS and tumor microenvironment is pivotal for the development of more effective treatments, particularly for relapsed or refractory diseases.
Keyword Classical Hodgkin lymphoma
EBV-associated Hodgkin lymphoma
HIV-associated Hodgkin lymphoma
Hodgkin lymphoma
Microenvironment
Pathogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 14287 RD
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
Admin Only - UQ Diamantina Institute
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Feb 2017, 00:28:26 EST by System User on behalf of Learning and Research Services (UQ Library)