Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats

Whitehouse M.W., Fairlie D.P. and Thong Y.H. (1994) Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats. Agents and Actions, 42 3-4: 123-127. doi:10.1007/BF01983477


Author Whitehouse M.W.
Fairlie D.P.
Thong Y.H.
Title Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats
Journal name Agents and Actions   Check publisher's open access policy
ISSN 0065-4299
Publication date 1994-02-01
Year available 1994
Sub-type Article (original research)
DOI 10.1007/BF01983477
Open Access Status Not yet assessed
Volume 42
Issue 3-4
Start page 123
End page 127
Total pages 5
Place of publication BASEL
Publisher Birkhäuser-Verlag
Language eng
Abstract Two isoquinoline plant alkaloids, tetrandrine (1) and berbamine (2), have been evaluated for anti-inflammatory activity in an acute paw oedema assay and in adjuvant-induced arthritis in rats. 1 but not 2 suppressed the chronic inflammation in the arthritis model but neither compound was active in the acute inflammation assay. In the adjuvant-induced polyarthritis, 1 was not effective when given at the time of inoculation (Day 0), nor just before (Day 7-10) signs of arthritis were evident. However, when given on a therapeutic dose schedule (Days 10-13) or continually (Day -1 to +14) on a prophylactic schedule, signs of arthritis including weight loss due to cachexia were significantly reduced. Given orally, 1 was considerably more potent than aspirin but not gastro-irritant and may be a promising lead for the development of a safe and effective treatment of chronic inflammatory diseases.
Keyword Alkaloid
Anti-inflammatory
Arthritis
Isoquinoline
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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