Zinc monoglycerolate - A slow-release source of therapeutic zinc: Solubilization by endogenous ligands

Fairlie D.P., Whitehouse M.W. and Taylor R.M. (1992) Zinc monoglycerolate - A slow-release source of therapeutic zinc: Solubilization by endogenous ligands. Agents and Actions, 36 1-2: 152-158. doi:10.1007/BF01991243


Author Fairlie D.P.
Whitehouse M.W.
Taylor R.M.
Title Zinc monoglycerolate - A slow-release source of therapeutic zinc: Solubilization by endogenous ligands
Journal name Agents and Actions   Check publisher's open access policy
ISSN 0065-4299
Publication date 1992-02-01
Year available 1992
Sub-type Article (original research)
DOI 10.1007/BF01991243
Open Access Status Not yet assessed
Volume 36
Issue 1-2
Start page 152
End page 158
Total pages 7
Place of publication BASEL
Publisher Birkhäuser-Verlag
Language eng
Abstract A combination of Zn-65-tracer determinations, oxidative analyses for glycerol, and a bioassay for uncomplexed Zn2+ have shown that: (i) zinc monoglycerolate (ZMG) dissolves in aqueous salt solutions/physiological media by dissociation into zinc ions and glycerol, but the rate and extent of ZMG dissolution depend upon pH, and/or concentration and complexing efficiency of zinc-ligands; (ii) under physiological conditions certain ligands present in skin and blood (e.g. citrate, lactate, albumin, histidine, glutathione and other thiols and, to a lesser extent, amino acids) accelerate ZMG dissolution; and (iii) there is a general correlation between the conditional stability constants (pH 7.3, 25-degrees-C) of zinc-ligand complexes and the ability of given ligands to (a) solubilize ZMG in vitro and (b) mask the irritancy of Zn2+ in vivo. These observations indicate a mechanism for the transformation of ZMG applied transdermally or subcutaneously, to bioactive zinc (anti-arthritic nutritional supplement, etc.).
Keyword Chemistry, Multidisciplinary
Pharmacology & Pharmacy
Chemistry
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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