Alpha helix nucleation by a simple cyclic tetrapeptide

Hoang, Huy N., Wu, Chongyang, Beyer, Renee L., Hill, Timothy A. and Fairlie, David P. (2017) Alpha helix nucleation by a simple cyclic tetrapeptide. Australian Journal of Chemistry, 70 2: 213-219. doi:10.1071/CH16591


Author Hoang, Huy N.
Wu, Chongyang
Beyer, Renee L.
Hill, Timothy A.
Fairlie, David P.
Title Alpha helix nucleation by a simple cyclic tetrapeptide
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 1445-0038
0004-9425
Publication date 2017-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1071/CH16591
Open Access Status Not yet assessed
Volume 70
Issue 2
Start page 213
End page 219
Total pages 7
Place of publication Clayton, VIC, Australia
Publisher C S I R O Publishing
Language eng
Formatted abstract
The simple cyclic tetrapeptide cyclo-(1,4)-[Ala-Arg-Ala-homoGlu]-NH2 (3) is shown to adopt an unusual α-turn structure, which is not α-helical but can nucleate α-helicity when attached to the N-terminus of either model peptides or two biologically relevant peptides. This new N-terminal helix-capping macrocycle provides very simple and rapid synthetic access to α-helical peptide structures
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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