Physically realizable three-dimensional bone prosthesis design with interpolated microstructures

Cramer, Andrew D. , Challis, Vivien J. and Roberts, Anthony P. (2017) Physically realizable three-dimensional bone prosthesis design with interpolated microstructures. Journal of Biomechanical Engineering, 139 3: . doi:10.1115/1.4035481

Author Cramer, Andrew D.
Challis, Vivien J.
Roberts, Anthony P.
Title Physically realizable three-dimensional bone prosthesis design with interpolated microstructures
Journal name Journal of Biomechanical Engineering   Check publisher's open access policy
ISSN 1528-8951
Publication date 2017-03-01
Year available 2017
Sub-type Article (original research)
DOI 10.1115/1.4035481
Open Access Status Not yet assessed
Volume 139
Issue 3
Total pages 8
Place of publication New York, NY, United States
Publisher American Society of Mechanical Engineers
Language eng
Subject 2204 Biomedical Engineering
2737 Physiology (medical)
Abstract We present a new approach to designing three-dimensional, physically realizable porous femoral implants with spatially varying microstructures and effective material properties. We optimize over a simplified design domain to reduce shear stress at the bone-prosthetic interface with a constraint on the bone resorption measured using strain energy. This combination of objective and constraint aims to reduce implant failure and allows a detailed study of the implant designs obtained with a range of microstructure sets and parameters. The microstructure sets are either specified directly or constructed using shape interpolation between a finite number of microstructures optimized for multifunctional characteristics. We demonstrate that designs using varying microstructures outperform designs with a homogeneous microstructure for this femoral implant problem. Further, the choice of microstructure set has an impact on the objective values achieved and on the optimized implant designs. A proof-of-concept metal prototype fabricated via selective laser melting (SLM) demonstrates the manufacturability of designs obtained with our approach.
Keyword Biophysics
Engineering, Biomedical
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP110101653
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
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