Long-term outcomes of Murray Valley encephalitis cases in Western Australia: What have we learnt?

Selvey, L.A., Speers, D.J. and Smith, D.W. (2016) Long-term outcomes of Murray Valley encephalitis cases in Western Australia: What have we learnt?. Internal Medicine Journal, 46 2: 193-201. doi:10.1111/imj.12962


Author Selvey, L.A.
Speers, D.J.
Smith, D.W.
Title Long-term outcomes of Murray Valley encephalitis cases in Western Australia: What have we learnt?
Journal name Internal Medicine Journal   Check publisher's open access policy
ISSN 1445-5994
1444-0903
Publication date 2016-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/imj.12962
Open Access Status Not yet assessed
Volume 46
Issue 2
Start page 193
End page 201
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background
Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus that causes encephalitis in some cases of infection. It is endemic in Northern Australia and cases occasionally occur in South Eastern Australia. The long-term sequelae of MVEV infection have not previously been well described.

Aim
To investigate the long-term sequelae of MVEV infection.

Methods
This was a descriptive case series of all clinical MVEV infections using data linkage and standard surveys. Hospital admissions, emergency department, psychiatric outpatients and mortality data were obtained. We attempted to follow-up all 53 cases of MVEV clinical infection that occurred in Western Australia from 1978 to 2011 inclusive. Two cases opted out of the study.

Results
We followed-up 39 surviving cases. Seven of the nine with paralysis or paresis were under 5 years and they fared worse than other patients, requiring lengthy hospitalisation (median duration 133 days). Two died due to complications of quadriplegia following a total of 691 days in hospital. Nine surviving patients, including two with non-encephalitic illness, required care for depression and other psychiatric conditions following MVEV infection. Two patients who were discharged with neurological sequelae had no further documented hospital occasions of service but reported ongoing challenges with cognitive dysfunction and inability to work.

Conclusions
This is the first study of long-term outcomes of Murray Valley encephalitis that included cases with no obvious sequelae at discharge. In spite of the small numbers involved, the study demonstrated the significant medical and social burden due to MVEV in Australia.
Keyword Arbovirus
Australia
Encephalitis
Flavivirus
Murray Valley encephalitis virus
Sequelae
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
 
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