Exosomes: key mediators of metastasis and pre-metastatic niche formation

Lobb, Richard J., Lima, Luize G. and Moller, Andreas (2017) Exosomes: key mediators of metastasis and pre-metastatic niche formation. Seminars in Cell and Developmental Biology, 67 3-10. doi:10.1016/j.semcdb.2017.01.004

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Author Lobb, Richard J.
Lima, Luize G.
Moller, Andreas
Title Exosomes: key mediators of metastasis and pre-metastatic niche formation
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1096-3634
Publication date 2017-01-08
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2017.01.004
Open Access Status File (Author Post-print)
Volume 67
Start page 3
End page 10
Total pages 8
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Abstract While tumour cells are classically known to communicate via direct cell-to-cell contact and the secretion of soluble protein-based factors such as cytokines and growth factors, alternative novel mechanisms that promote tumour progression have recently emerged. Now, new critical components of the secretome thought to be involved in tumour progression are exosomes, small vesicles of endocytic origin that carry a variety of bioactive molecules, including proteins, lipids, RNA, as well as DNA molecules. Cancer cell-derived exosomes have been shown to participate in crucial steps of metastatic spread of a primary tumour, ranging from oncogenic reprogramming of malignant cells to formation of pre-metastatic niches. These effects are achieved through the mediation of intercellular cross-talk and subsequent modification of both local and distant microenvironments in an autocrine and paracrine fashion. Here, we summarise the recent findings that implicate this non-canonical signalling within the tumour as a critical driver of metastatic disease progression, and discuss how understanding the molecular mechanisms involved in exosome-mediated metastasis is of great value for the development of new therapeutic strategies to prevent cancer progression.
Keyword Cancer
Extracellular vesicles
Pre-metastatic niche
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Clinical Medicine Publications
Admin Only - School of Clinical Medicine
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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