Long-term mortality following Pseudomonas aeruginosa bloodstream infection

McCarthy, K. L. and Paterson, D. L. (2016) Long-term mortality following Pseudomonas aeruginosa bloodstream infection. Journal of Hospital Infection, 95 3: 292-299. doi:10.1016/j.jhin.2016.11.014

Author McCarthy, K. L.
Paterson, D. L.
Title Long-term mortality following Pseudomonas aeruginosa bloodstream infection
Formatted title
Long-term mortality following Pseudomonas aeruginosa bloodstream infection
Journal name Journal of Hospital Infection   Check publisher's open access policy
ISSN 1532-2939
Publication date 2016-11-30
Sub-type Article (original research)
DOI 10.1016/j.jhin.2016.11.014
Open Access Status Not yet assessed
Volume 95
Issue 3
Start page 292
End page 299
Total pages 8
Place of publication London, United Kingdom
Publisher W. B. Saunders Co.
Collection year 2018
Language eng
Formatted abstract
Background: Pseudomonas aeruginosa bloodstream infections (BSI) are associated with substantial short-term mortality. There is little data on long-term mortality associated with this BSI.

Aim: To describe mortality rates up to one year post infection and the significant factors associated with death.

Methods: Positive blood cultures for P. aeruginosa were identified retrospectively from January 2008 to January 2011 at seven tertiary care hospitals. Extensive epidemiological, clinical and outcome data were obtained.

Findings: Three hundred and eighty-eight BSI episodes were included in the analysis. The majority of infections were hospital acquired. The most common patient comorbidities were haematological or oncological. Seventy-eight percent of the cohort had a medical device in situ in the preceding seven days. Sixty-one percent of the cohort received adequate empirical therapy. All-cause mortality was 4% at 48 h, 19% at one month and 38% at one year. Forty-eight-hour mortality was associated with non-hospital-acquired infection, pulmonary comorbidity, recent corticosteroid therapy, and a Pitt bacteraemia score >2. Comorbidities became significantly associated with mortality from seven days post infection. Long-term mortality (defined as mortality at one year) was associated with female sex, haematological or oncological comorbidity, a Charlson comorbidity index >2 and recent corticosteroid therapy.

Conclusion: The exact role of infection, from this highly virulent pathogen, in the cause of death over time needs to be studied further. It is not clear if patients are dying from or with P. aeruginosa BSI.
Keyword Bacteraemia
Bloodstream infection
Pseudomonas aeruginosa
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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