Developmental vitamin D deficiency and autism: putative pathogenic mechanisms

Ali, Asad, Cui, Xiaoying and Eyles, Darryl (2016) Developmental vitamin D deficiency and autism: putative pathogenic mechanisms. Journal of Steroid Biochemistry and Molecular Biology, 175 108-118. doi:10.1016/j.jsbmb.2016.12.018

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Author Ali, Asad
Cui, Xiaoying
Eyles, Darryl
Title Developmental vitamin D deficiency and autism: putative pathogenic mechanisms
Journal name Journal of Steroid Biochemistry and Molecular Biology   Check publisher's open access policy
ISSN 1879-1220
0960-0760
Publication date 2016-12-24
Sub-type Article (original research)
DOI 10.1016/j.jsbmb.2016.12.018
Open Access Status File (Author Post-print)
Volume 175
Start page 108
End page 118
Total pages 11
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
1303 Biochemistry
1313 Molecular Medicine
1312 Molecular Biology
1310 Endocrinology
1308 Clinical Biochemistry
1307 Cell Biology
Abstract Autism is a neurodevelopmental disease that presents in early life. Despite a considerable amount of studies, the neurobiological mechanisms underlying autism remain obscure. Both genetic and environmental factors are involved in the development of autism. Vitamin D deficiency is emerging as a consistently reported risk factor in children. One reason for the prominence now being given to this risk factor is that it would appear to interact with several other epidemiological risk factors for autism. Vitamin D is an active neurosteroid and plays crucial neuroprotective roles in the developing brain. It has important roles in cell proliferation and differentiation, immunomodulation, regulation of neurotransmission and steroidogenesis. Animal studies have suggested that transient prenatal vitamin D deficiency is associated with altered brain development. Here we review the potential neurobiological mechanisms linking prenatal vitamin D deficiency and autism and also discuss what future research targets must now be addressed.
Keyword Autism
Brain
Mechanisms
Neurodevelopment
Vitamin D
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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