Measuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectives

Gracia-Lor, Emma, Castiglioni, Sara, Bade, Richard, Been, Frederic, Castrignano, Erika, Covaci, Adrian, Gonzalez-Marino, Iria, Hapeshi, Evroula, Kasprzyk-Hordern, Barbara, Kinyua, Juliet, Lai, Foon Yin, Letzel, Thomas, Lopardo, Luigi, Meyer, Markus R., O'Brien, Jake, Ramin, Pedram, Rousis, Nikolaos I., Rydevik, Axel, Ryu, Yeonsuk, Santos, Miguel M., Senta, Ivan, Thomaidis, Nikolaos S., Veloutsou, Sofia, Yang, Zhugen, Zuccato, Ettore and Bijlsma, Lubertus (2017) Measuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectives. Environment International, 99 131-150. doi:10.1016/j.envint.2016.12.016

Author Gracia-Lor, Emma
Castiglioni, Sara
Bade, Richard
Been, Frederic
Castrignano, Erika
Covaci, Adrian
Gonzalez-Marino, Iria
Hapeshi, Evroula
Kasprzyk-Hordern, Barbara
Kinyua, Juliet
Lai, Foon Yin
Letzel, Thomas
Lopardo, Luigi
Meyer, Markus R.
O'Brien, Jake
Ramin, Pedram
Rousis, Nikolaos I.
Rydevik, Axel
Ryu, Yeonsuk
Santos, Miguel M.
Senta, Ivan
Thomaidis, Nikolaos S.
Veloutsou, Sofia
Yang, Zhugen
Zuccato, Ettore
Bijlsma, Lubertus
Title Measuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectives
Journal name Environment International   Check publisher's open access policy
ISSN 1873-6750
Publication date 2017-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.envint.2016.12.016
Open Access Status Not yet assessed
Volume 99
Start page 131
End page 150
Total pages 20
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2300 Environmental Science
Abstract The information obtained from the chemical analysis of specific human excretion products (biomarkers) in urban wastewater can be used to estimate the exposure or consumption of the population under investigation to a defined substance. A proper biomarker can provide relevant information about lifestyle habits, health and wellbeing, but its selection is not an easy task as it should fulfil several specific requirements in order to be successfully employed. This paper aims to summarize the current knowledge related to the most relevant biomarkers used so far. In addition, some potential wastewater biomarkers that could be used for future applications were evaluated. For this purpose, representative chemical classes have been chosen and grouped in four main categories: (i) those that provide estimates of lifestyle factors and substance use, (ii) those used to estimate the exposure to toxicants present in the environment and food, (iii) those that have the potential to provide information about public health and illness and (iv) those used to estimate the population size. To facilitate the evaluation of the eligibility of a compound as a biomarker, information, when available, on stability in urine and wastewater and pharmacokinetic data (i.e. metabolism and urinary excretion profile) has been reviewed. Finally, several needs and recommendations for future research are proposed.
Keyword Biomarker
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ES1307
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
National Research Centre for Environmental Toxicology Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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