Review: Placental mitochondrial function and structure in gestational disorders

Holland, Olivia, Dekker Nitert, Marloes, Gallo, Linda A., Vejzovic, Meliha, Fisher, Joshua J. and Perkins, Anthony V. (2016) Review: Placental mitochondrial function and structure in gestational disorders. Placenta, 54 2-9. doi:10.1016/j.placenta.2016.12.012

Author Holland, Olivia
Dekker Nitert, Marloes
Gallo, Linda A.
Vejzovic, Meliha
Fisher, Joshua J.
Perkins, Anthony V.
Title Review: Placental mitochondrial function and structure in gestational disorders
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2016-12-14
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.012
Open Access Status Not yet assessed
Volume 54
Start page 2
End page 9
Total pages 8
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 2743 Reproductive Medicine
2729 Obstetrics and Gynaecology
1309 Developmental Biology
Abstract The aetiology of many gestational disorders is still unknown. However, insufficient trans-placental nutrient and oxygen transfer due to abnormal placentation is characteristic of several pathologies, and may alter the function of placental mitochondria. Mitochondria are multifunctional organelles that respond to a wide range of stimuli - such as physiological changes in cellular energy demands or various pathologies - by reshaping via fusion or fission, increasing/decreasing in number, altering oxidative phosphorylation, and signalling cellular functions such as apoptosis. Mitochondrial function is integral to tissue functions including energy production, metabolism, and regulation of various cellular responses including response to oxidative stress. This review details the functions of placental mitochondria and investigates mitochondrial function and structure in gestational disorders including preeclampsia, intrauterine growth restriction, diabetes mellitus, and obesity. Placental mitochondrial dysfunction may be critical in a range of gestational disorders which have important implications for maternal and fetal/offspring health.
Keyword Diabetes
Intrauterine growth restriction
Oxidative stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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