Peptide-mediated cellular delivery of semiconductor quantum dots

Gemmill, K.B., Muttenthaler, M., Delehanty, J., Deschamps, J., Susumu, K., Stewart, M., Dawson, P., Huston, A. and Medintz, I. (2013). Peptide-mediated cellular delivery of semiconductor quantum dots. In: Šárka O. Southern, Conference on Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, Baltimore, United States, (). Apr 29-May 01, 2013. doi:10.1117/12.2015446


Author Gemmill, K.B.
Muttenthaler, M.
Delehanty, J.
Deschamps, J.
Susumu, K.
Stewart, M.
Dawson, P.
Huston, A.
Medintz, I.
Title of paper Peptide-mediated cellular delivery of semiconductor quantum dots
Conference name Conference on Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III
Conference location Baltimore, United States
Conference dates Apr 29-May 01, 2013
Journal name Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III   Check publisher's open access policy
Place of Publication Bellingham, WA, United States
Publisher S P I E - International Society for Optical Engineering
Publication Year 2013
Year available 2013
Sub-type Fully published paper
DOI 10.1117/12.2015446
Open Access Status Not yet assessed
ISBN 9780819495143
ISSN 0277-786X
1996-756X
Editor Šárka O. Southern
Volume 8723
Total pages 6
Language eng
Abstract/Summary CdSe/ZnS semiconductor quantum dots (QDs) are ideal materials for biological sensing and cellular imaging applications due to their superior photophysical properties in comparison to fluorescent proteins or dyes and their ease of conjugation to biological materials. We have previously developed a number of in vitro FRET based biosensors in the laboratory for detection of proteases and biological and chemical agents. We would like to expand these biosensing capabilities into cellular systems, requiring development of QD cellular delivery techniques. Peptide-mediated cellular delivery of QDs is ideal as peptides are small, easily conjugated to QDs, easily manipulated and synthesized, and can be designed with "handles" for further chemical conjugation with other cargo. Here we discuss four cell delivery peptides that facilitate QD uptake in live cells. Understanding these peptides will help us design better nanoparticle cellular delivery systems and advance our capabilities for in vivo biosensing.
Formatted Abstract/Summary
CdSe/ZnS semiconductor quantum dots (QDs) are ideal materials for biological sensing and cellular imaging applications due to their superior photophysical properties in comparison to fluorescent proteins or dyes and their ease of conjugation to biological materials. We have previously developed a number of in vitro FRET based biosensors in the laboratory for detection of proteases and biological and chemical agents. We would like to expand these biosensing capabilities into cellular systems, requiring development of QD cellular delivery techniques. Peptide mediated cellular delivery of QDs is ideal as peptides are small, easily conjugated to QDs, easily manipulated and synthesized, and can be designed with “handles” for further chemical conjugation with other cargo. Here we discuss four cell delivery peptides that facilitate QD uptake in live cells. Understanding these peptides will help us design better nanoparticle cellular delivery systems and advance our capabilities for in vivo biosensing.
Keyword Fluorescent
Imaging
Nanoparticle
Peptide
Quantum dots
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collection: Institute for Molecular Bioscience - Publications
 
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