Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy

Chen, Min, Arumugam, Thiruma V., Leanage, Gayeshika, Tieng, Quang M., Yadav, Ashwin, Ullmann, Jeremy F. P., She, David T., Truong, Vy, Ruitenberg, Marc J. and Reutens, David C. (2017) Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy. Scientific Reports, 7 . doi:10.1038/srep40528


Author Chen, Min
Arumugam, Thiruma V.
Leanage, Gayeshika
Tieng, Quang M.
Yadav, Ashwin
Ullmann, Jeremy F. P.
She, David T.
Truong, Vy
Ruitenberg, Marc J.
Reutens, David C.
Title Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-01-11
Sub-type Article (original research)
DOI 10.1038/srep40528
Open Access Status DOI
Volume 7
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Novel therapies that prevent or modify the development of epilepsy following an initiating brain insult could significantly reduce the burden of this disease. In light of evidence that immune mechanisms play an important role in generating and maintaining the epileptic condition, we evaluated the effect of a well-established immunomodulatory treatment, intravenous immunoglobulin (IVIg), on the development of epilepsy in an experimental model of epileptogenesis. In separate experiments, IVIg was administered either before (pre-treatment) or after (post-treatment) the onset of pilocarpine status epilepticus (SE). Our results show that both pre-and post-treatment with IVIg attenuated acute inflammation in the SE model. Specifically, IVIg reduced local activation of glial cells, complement system activation, and blood-brain barrier damage (BBB), which are all thought to play important roles in the development of epilepsy. Importantly, post-treatment with IVIg was also found to reduce the frequency and duration of subsequent spontaneous recurrent seizures as detected by chronic video-electroencephalographic (video-EEG) recordings. This finding supports a novel application for IVIg, specifically its repurposing as a disease-modifying therapy in epilepsy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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