The role of neuropeptides in adverse myocardial remodeling and heart failure

Widiapradja, Alexander, Chunduri, Prasad and Levick, Scott P. (2017) The role of neuropeptides in adverse myocardial remodeling and heart failure. Cellular and Molecular Life Sciences, 74 11: 2019-2038. doi:10.1007/s00018-017-2452-x

Author Widiapradja, Alexander
Chunduri, Prasad
Levick, Scott P.
Title The role of neuropeptides in adverse myocardial remodeling and heart failure
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-9071
Publication date 2017-01-17
Year available 2017
Sub-type Article (original research)
DOI 10.1007/s00018-017-2452-x
Open Access Status Not yet assessed
Volume 74
Issue 11
Start page 2019
End page 2038
Total pages 20
Place of publication Basel, Switzerland
Publisher Springer
Language eng
Subject 1313 Molecular Medicine
1312 Molecular Biology
3004 Pharmacology
2804 Cellular and Molecular Neuroscience
1307 Cell Biology
Abstract In addition to traditional neurotransmitters of the sympathetic and parasympathetic nervous systems, the heart also contains numerous neuropeptides. These neuropeptides not only modulate the effects of neurotransmitters, but also have independent effects on cardiac function. While in most cases the physiological actions of these neuropeptides are well defined, their contributions to cardiac pathology are less appreciated. Some neuropeptides are cardioprotective, some promote adverse cardiac remodeling and heart failure, and in the case of others their functions are unclear. Some have both cardioprotective and adverse effects depending on the specific cardiac pathology and progression of that pathology. In this review, we briefly describe the actions of several neuropeptides on normal cardiac physiology, before describing in more detail their role in adverse cardiac remodeling and heart failure. It is our goal to bring more focus toward understanding the contribution of neuropeptides to the pathogenesis of heart failure, and to consider them as potential therapeutic targets.
Keyword Cardiac remodeling
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R00 HL093215
R56 HL132908
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
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