Topical and cutaneous delivery using nanosystems

Roberts, M. S., Mohammed, Y., Pastore, M. N., Namjoshi, S., Yousef, S., Alinaghi, A., Haridass, I. N., Abd, E., Leite-Silva, V. R., Benson, H. A. E. and Grice, J. E. (2017) Topical and cutaneous delivery using nanosystems. Journal of Controlled Release, 247 86-105. doi:10.1016/j.jconrel.2016.12.022

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Author Roberts, M. S.
Mohammed, Y.
Pastore, M. N.
Namjoshi, S.
Yousef, S.
Alinaghi, A.
Haridass, I. N.
Abd, E.
Leite-Silva, V. R.
Benson, H. A. E.
Grice, J. E.
Title Topical and cutaneous delivery using nanosystems
Journal name Journal of Controlled Release   Check publisher's open access policy
ISSN 1873-4995
Publication date 2017-02-10
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jconrel.2016.12.022
Open Access Status File (Author Post-print)
Volume 247
Start page 86
End page 105
Total pages 20
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 3003 Pharmaceutical Science
Abstract The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review.
Keyword Colloidal nanocarrier systems
Cutaneous delivery
Topical delivery
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1002611
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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