Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes

Yeshurun, Shlomo, Short, Annabel K., Bredy, Timothy W., Pang, Terence Y. and Hannan, Anthony J. (2017) Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes. Psychoneuroendocrinology, 77 225-235. doi:10.1016/j.psyneuen.2016.11.013

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Author Yeshurun, Shlomo
Short, Annabel K.
Bredy, Timothy W.
Pang, Terence Y.
Hannan, Anthony J.
Title Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 1873-3360
Publication date 2017-03-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.psyneuen.2016.11.013
Open Access Status File (Author Post-print)
Volume 77
Start page 225
End page 235
Total pages 11
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
1310 Endocrinology
2807 Endocrine and Autonomic Systems
2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract Recent studies have demonstrated that paternal stress in rodents can result in modification of offspring behavior. Environmental enrichment, which enhances cognitive stimulation and physical activity, modifies various behaviors and reduces stress responses in adult rodents. We investigated the transgenerational influence of paternal environmental enrichment on offspring behavior and physiological stress response. Adult C57BL/6J male mice (F0) were exposed to either environmental enrichment or standard housing for four weeks and then pair-mated with naïve females. The F2 generation was generated using F1 male offspring. Male and female F1 and F2 offspring were tested for anxiety using the elevated-plus maze and large open field at 8 weeks of age. Depression-related behavior was assessed using the forced-swim test. Hypothalamic-pituitary-adrenal (HPA) axis function was determined by quantification of serum corticosterone and adrenocorticotropic hormone (ACTH) levels at baseline and after forced-swim stress. Paternal environmental enrichment was associated with increased body weights of male F1 and F2 offspring. There was no significant effect on F1 offspring anxiety and depression-related behaviors. There were no changes in anxiety-related behaviors in the F2 offspring, however these mice displayed a reduced latency to immobility in the forced-swim test. Furthermore, F2 females had significantly higher serum corticosterone levels post-stress, but not ACTH. These results show that paternal environmental enrichment exerts a sex-specific transgenerational impact on the behavioral and physiological response to stress. Our findings have implications for the modelling of psychiatric disorders in rodents.
Keyword Corticosterone
Environmental enrichment
Epigenetic inheritance
HPA axis
Stress response
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1083468
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
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