Towards the structure of the TIR-domain signalosome

Nimma, Surekha, Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2017) Towards the structure of the TIR-domain signalosome. Current Opinion In Structural Biology, 43 122-130. doi:10.1016/

Author Nimma, Surekha
Ve, Thomas
Williams, Simon J.
Kobe, Bostjan
Title Towards the structure of the TIR-domain signalosome
Journal name Current Opinion In Structural Biology   Check publisher's open access policy
ISSN 1879-033X
Publication date 2017-04-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/
Open Access Status Not yet assessed
Volume 43
Start page 122
End page 130
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
TIR (Toll/interleukin-1 receptor/resistance protein) domains feature in animal, plant and bacterial proteins involved in innate immunity pathways and associated processes. They function through protein:protein interactions, in particular self-association and homotypic association with other TIR domains. Structures of TIR domains from all phyla have been determined, but common association modes have only emerged for plant and bacterial TIR domains, and not for mammalian TIR domains. Numerous attempts involving hybrid approaches, which have combined structural, computational, mutagenesis and biophysical data, have failed to converge onto common models of how these domains associate and function. We propose that the available data can be reconciled in the context of higher-order assembly formation, and that TIR domains function through signaling by cooperative assembly formation (SCAF).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Fri, 27 Jan 2017, 23:54:22 EST by Mrs Louise Nimwegen on behalf of Learning and Research Services (UQ Library)