The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries

McGrath, J. J., McLaughlin, K. A., Saha, S., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., Bruffaerts, R., de Girolamo, G., de Jonge, P., Esan, O., Florescu, S., Gureje, O., Haro, J. M., Hu, C., Karam, E. G., Kovess-Masfety, V., Lee, S., Lepine, J. P., Lim, C. C. W., Medina-Mora, M. E., Mneimneh, Z., Pennell, B. E., Piazza, M., Posada-Villa, J., Sampson, N., Viana, M. C., Xavier, M., Bromet, E. J., Kendler, K. S. and Kessler, R. C. (2017) The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries. Psychological Medicine, 1-16. doi:10.1017/S0033291716003263


Author McGrath, J. J.
McLaughlin, K. A.
Saha, S.
Aguilar-Gaxiola, S.
Al-Hamzawi, A.
Alonso, J.
Bruffaerts, R.
de Girolamo, G.
de Jonge, P.
Esan, O.
Florescu, S.
Gureje, O.
Haro, J. M.
Hu, C.
Karam, E. G.
Kovess-Masfety, V.
Lee, S.
Lepine, J. P.
Lim, C. C. W.
Medina-Mora, M. E.
Mneimneh, Z.
Pennell, B. E.
Piazza, M.
Posada-Villa, J.
Sampson, N.
Viana, M. C.
Xavier, M.
Bromet, E. J.
Kendler, K. S.
Kessler, R. C.
Title The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries
Journal name Psychological Medicine   Check publisher's open access policy
ISSN 1469-8978
0033-2917
Publication date 2017-01-09
Sub-type Article (original research)
DOI 10.1017/S0033291716003263
Open Access Status Not yet assessed
Start page 1
End page 16
Total pages 16
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2018
Language eng
Formatted abstract
Background. Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations.

Method. We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models.

Results. Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9–2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6–20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF).

Conclusions. Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.

Keyword Childhood adversity
Discrete-time survival analysis
Maladaptive family functioning
Population attributable risk proportion
Psychotic experiences
World Mental Health survey
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 9 January 2017

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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