Development and validation of a quality-of-life questionnaire for patients with oral potentially malignant disorders

Tadakamadla, Jyothi, Kumar, Santhosh, Lalloo, Ratilal and Johnson, Newell W. (2017) Development and validation of a quality-of-life questionnaire for patients with oral potentially malignant disorders. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 123 3: 338-349. doi:10.1016/j.oooo.2016.10.025


Author Tadakamadla, Jyothi
Kumar, Santhosh
Lalloo, Ratilal
Johnson, Newell W.
Title Development and validation of a quality-of-life questionnaire for patients with oral potentially malignant disorders
Journal name Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology   Check publisher's open access policy
ISSN 2212-4403
2212-4411
Publication date 2017-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.oooo.2016.10.025
Open Access Status Not yet assessed
Volume 123
Issue 3
Start page 338
End page 349
Total pages 12
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Abstract The aim of this study was to develop and evaluate the validity and reliability of a quality-of-life (QoL) questionnaire for patients with oral potentially malignant disorders (OPMDs).

For item generation, 15 personal interviews and three focus group discussions were conducted with OPMD patients existing QoL questionnaires were reviewed, and inputs from specialist clinicians (n = 10) were considered. Data collected from patients were analyzed by using NVivo. This led to the identification of themes, item writing, scaling, item reduction, formatting, and pretesting of the newly developed questionnaire. The validity and reliability of the questionnaire were assessed in a separate sample of 300 patients (150 each of patients with OPMD and healthy individuals).

Sixty items were generated from the qualitative data and by reviewing existing questionnaires. After item reduction, the final questionnaire comprised 20 questions, which could be categorized under four domains. Exploratory factor analysis revealed a four-factor structure conforming to the four domains. The OPMD QoL questionnaire exhibited good discriminant and convergent validity, with OPMD patients reporting poorer QoL compared with healthy individuals and correlating significantly with existing questionnaires designed for similar purposes respectively.

Our OPMD QoL questionnaire was found to be valid and reliable. We recommend that it be applied in epidemiologic and treatment studies of these disorders.
Formatted abstract
Objective
The aim of this study was to develop and evaluate the validity and reliability of a quality-of-life (QoL) questionnaire for patients with oral potentially malignant disorders (OPMDs).

Study Design
For item generation, 15 personal interviews and three focus group discussions were conducted with OPMD patients existing QoL questionnaires were reviewed, and inputs from specialist clinicians (n = 10) were considered. Data collected from patients were analyzed by using NVivo. This led to the identification of themes, item writing, scaling, item reduction, formatting, and pretesting of the newly developed questionnaire. The validity and reliability of the questionnaire were assessed in a separate sample of 300 patients (150 each of patients with OPMD and healthy individuals).

Results
Sixty items were generated from the qualitative data and by reviewing existing questionnaires. After item reduction, the final questionnaire comprised 20 questions, which could be categorized under four domains. Exploratory factor analysis revealed a four-factor structure conforming to the four domains. The OPMD QoL questionnaire exhibited good discriminant and convergent validity, with OPMD patients reporting poorer QoL compared with healthy individuals and correlating significantly with existing questionnaires designed for similar purposes respectively.

Conclusions
Our OPMD QoL questionnaire was found to be valid and reliable. We recommend that it be applied in epidemiologic and treatment studies of these disorders.
Keyword Dentistry, Oral Surgery & Medicine
Dentistry, Oral Surgery & Medicine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Dentistry Publications
 
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Created: Mon, 23 Jan 2017, 17:08:37 EST by Mary-Anne Marrington on behalf of Learning and Research Services (UQ Library)